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10.1097/MD.0000000000001528 http://scihub22266oqcxt.onion/10.1097/MD.0000000000001528 C4620762!4620762!26496255     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26496255.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Medicine+(Baltimore) 2015 ; 94 (42): ä Nephropedia Template TP {{tp|p=26496255|t=2015. Proinflammatory Cytokines and Antiskin Autoantibodies in Patients With Inherited Epidermolysis Bullosa |pdf=|usr=}}{{26496255}} gab.com Text Proinflammatory Cytokines and Antiskin Autoantibodies in Patients With Inherited Epidermolysis Bullosa JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26496255 #FOAvip Epidermolysis bullosa (EB) is a rare disorder characterized by inherited skin adhesion defects with abnormal disruption of the epidermal?dermal junction in response to mechanical trauma. Our aim was to investigate a set of cytokine levels in serum samples from patients suffering from epidermolysis bullosa simplex (EBS), dystrophic epidermolysis bullosa (DEB), and healthy controls (HCs), exploring their potential correlations with antiskin autoantibody titers and disease activity. Forty patients afferent to the Dermatological Ward of Bari City Hospital and 9 HCs were enrolled and subdivided according to the dystrophic (DEB) and simplex forms (EBS). We found a significant increase in interleukin (IL)-1? plasmatic levels of DEB (P?=?0.0224) and EBS (P?=?0.0465) patients compared to HCs; IL-6 levels were significantly higher in DEB than in EBS patients (P?=?0.0004) or HCs (P?=?0.0474); IL-2 levels were significantly increased in DEB compared with EBS (P?=?0.0428). Plasmatic tumor necrosis factor-? and interferon-? were higher in DEB patients than in HCs (P?=?0.0448 and 0.0229). Conversely, tumor necrosis factor-? was significantly decreased in DEB (P?=?0.0034). IL-5 correlated with anti-BP180 (r?=??0.5018, P?=?0.0338), anti-BP230 (r?=??0.6097, P?=?0.0122), and anticollagen VII (r?=??0.5166, P?=?0.0405) autoantibodies; interferon-? correlated with anti-BP180 (r?=?0.9633, P?<?0.0001), anti-BP230 (r?=?0.9071, P?<?0.0001), and anticollagen VII (r?=?0.8619, P?=?0.0045) autoantibodies. Score of disease severity was significantly correlated with IL-6 (r?=?0.6941, P?=?0.029) and IL-12 (r?=?0.5503, P?=?0.0272). The present study supports that EB might be considered a systemic inflammatory disease rather than a skin-limited disorder; clinical disease activity scores could be also integrated by laboratory data such as IL-6 and IL-12 dosage; biotherapies targeting specific cytokine networks probably represent a way to go in the future. Twit Text FOAVip Proinflammatory Cytokines and Antiskin Autoantibodies in Patients With Inherited Epidermolysis Bullosa ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26496255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26496255 #FOAvip English Wikipedia <ref>{{Cite pmid|26496255}}</ref> Proinflammatory Cytokines and Antiskin Autoantibodies in Patients With Inherited Epidermolysis Bullosa #MMPMID26496255 Annicchiarico G; Morgese MG; Esposito S; Lopalco G; Lattarulo M; Tampoia M; Bonamonte D; Brunetti L; Vitale A; Lapadula G; Cantarini L; Iannone F Medicine (Baltimore) 2015[Oct]; 94 (42): ä PMID26496255show ga Epidermolysis bullosa (EB) is a rare disorder characterized by inherited skin adhesion defects with abnormal disruption of the epidermal?dermal junction in response to mechanical trauma. Our aim was to investigate a set of cytokine levels in serum samples from patients suffering from epidermolysis bullosa simplex (EBS), dystrophic epidermolysis bullosa (DEB), and healthy controls (HCs), exploring their potential correlations with antiskin autoantibody titers and disease activity. Forty patients afferent to the Dermatological Ward of Bari City Hospital and 9 HCs were enrolled and subdivided according to the dystrophic (DEB) and simplex forms (EBS). We found a significant increase in interleukin (IL)-1? plasmatic levels of DEB (P?=?0.0224) and EBS (P?=?0.0465) patients compared to HCs; IL-6 levels were significantly higher in DEB than in EBS patients (P?=?0.0004) or HCs (P?=?0.0474); IL-2 levels were significantly increased in DEB compared with EBS (P?=?0.0428). Plasmatic tumor necrosis factor-? and interferon-? were higher in DEB patients than in HCs (P?=?0.0448 and 0.0229). Conversely, tumor necrosis factor-? was significantly decreased in DEB (P?=?0.0034). IL-5 correlated with anti-BP180 (r?=??0.5018, P?=?0.0338), anti-BP230 (r?=??0.6097, P?=?0.0122), and anticollagen VII (r?=??0.5166, P?=?0.0405) autoantibodies; interferon-? correlated with anti-BP180 (r?=?0.9633, P? äProinflammatory Cytokines and Antiskin Autoantibodies in Patients With(epmc).pdf DeepDyve Pubget Overpricing