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Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPAR?-ABCA1 pathway |pdf=|usr=}}{{26617799}} gab.com Text Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPAR -ABCA1 pathway JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617799 #FOAvip The accumulation of cholesterol in macrophages could induce the formation of foam cells and increase the risk of developing atherosclerosis. We wonder if quercetin, one of flavonoids with anti-inflammation functions in different cell types, could elevate the development of foam cells formation in atherosclerosis. We treated foam cells derived from oxLDL induced THP-1 cells with quercetin, and evaluated the foam cells formation, cholesterol content and apoptosis of the cells. We found that quercetin induced the expression of ABCA1 in differentiated THP-1 cells, and increased the cholesterol efflux from THP-1 cell derived foam cells. Eventually, cholesterol level and the formation of foam cell derived from THP-1 cells decreased after quercetin treatment. In addition, quercetin activated PPAR?-LXR? pathway to upregulate ABCA1 expression through increasing protein level of PPAR? and its transcriptional activity. Inhibition of PPAR? activity by siRNA knockdown or the addition of chemical inhibitor, GW9662, abolished quercetin induced ABCA1 expression and cholesterol efflux in THP-1 derived macrophages. Our data demonstrated that quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPAR? and ABCA1. Taken together, increasing uptake of quercetin or quercetin-rich foods would be an effective way to lower the risk of atherosclerosis. Twit Text FOAVip Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPAR -ABCA1 pathway ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617799 #FOAvip English Wikipedia <ref>{{Cite pmid|26617799}}</ref> Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPAR?-ABCA1 pathway #MMPMID26617799 Sun L; Li E; Wang F; Wang T; Qin Z; Niu S; Qiu C Int J Clin Exp Pathol 2015[]; 8 (9): 10854-60 PMID26617799show ga The accumulation of cholesterol in macrophages could induce the formation of foam cells and increase the risk of developing atherosclerosis. We wonder if quercetin, one of flavonoids with anti-inflammation functions in different cell types, could elevate the development of foam cells formation in atherosclerosis. We treated foam cells derived from oxLDL induced THP-1 cells with quercetin, and evaluated the foam cells formation, cholesterol content and apoptosis of the cells. We found that quercetin induced the expression of ABCA1 in differentiated THP-1 cells, and increased the cholesterol efflux from THP-1 cell derived foam cells. Eventually, cholesterol level and the formation of foam cell derived from THP-1 cells decreased after quercetin treatment. In addition, quercetin activated PPAR?-LXR? pathway to upregulate ABCA1 expression through increasing protein level of PPAR? and its transcriptional activity. Inhibition of PPAR? activity by siRNA knockdown or the addition of chemical inhibitor, GW9662, abolished quercetin induced ABCA1 expression and cholesterol efflux in THP-1 derived macrophages. Our data demonstrated that quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPAR? and ABCA1. Taken together, increasing uptake of quercetin or quercetin-rich foods would be an effective way to lower the risk of atherosclerosis. äQuercetin increases macrophage cholesterol efflux to inhibit foam cell(epmc).pdf DeepDyve Pubget Overpricing