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10.1371/journal.pone.0142103 http://scihub22266oqcxt.onion/10.1371/journal.pone.0142103 C4640880!4640880!26556804     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26556804&cmd=llinks): Failed to open stream: HTTP request failed! 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Long-Term Structural and Functional Myocardial Adaptations in Healthy Living Kidney Donors: A Pilot Study |pdf=|usr=}}{{26556804}} gab.com Text Long-Term Structural and Functional Myocardial Adaptations in Healthy Living Kidney Donors: A Pilot Study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26556804 #FOAvip Background and Aims: Compensatory renal hypertrophy following unilateral nephrectomy (UNX) occurs in the remaining kidney. However, the long-term cardiac adaptive process to UNX remains poorly defined in humans. Our goal was to characterize myocardial structure and function in living kidney donors (LKDs), approximately 12 years after UNX. Methods and Results: Cardiac function and structure in 15 Italian LKDs, at least 5 years after UNX (median time from donation = 8.4 years) was investigated and compared to those of age and sex matched U.S. citizens healthy controls (n = 15). Standard and speckle tracking echocardiography (STE) was performed in both LKDs and controls. Plasma angiotensin II, aldosterone, atrial natriuretic peptide (ANP), N terminus pro B-type natriuretic peptide (NT-proBNP), cyclic guanylyl monophosphate (cGMP), and amino-terminal peptide of procollagen III (PIIINP) were also collected. Median follow-up was 11.9 years. In LKDs, LV geometry and function by STE were similar to controls, wall thickness and volumes were within normal limits also by CMR. In LKDs, CMR was negative for myocardial fibrosis, but apical rotation and LV torsion obtained by STE were impaired as compared to controls (21.4 � 7.8 vs 32.7 � 8.9 degrees, p = 0.04). Serum creatinine and PIIINP levels were increased [1.1 (0.9?1.3) mg/dL, and 5.8 (5.4?7.6)] ?g/L, respectively), while urinary cGMP was reduced [270 (250?355) vs 581 (437?698) pmol/mL] in LKDs. No LKD developed cardiovascular or renal events during follow-up. Conclusions: Long-term kidney donors have no apparent structural myocardial abnormalities as assessed by contrast enhanced CMR. However, myocardial deformation of the apical segments, as well as apical rotation, and LV torsion are reduced. The concomitant increase in circulating PIIINP level is suggestive of fibrosis. Further studies, focused on US and EU patients are warranted to evaluate whether these early functional modifications will progress to a more compromised cardiac function and structure at a later time. Twit Text FOAVip Long-Term Structural and Functional Myocardial Adaptations in Healthy Living Kidney Donors: A Pilot Study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26556804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26556804 #FOAvip English Wikipedia <ref>{{Cite pmid|26556804}}</ref> Long-Term Structural and Functional Myocardial Adaptations in Healthy Living Kidney Donors: A Pilot Study #MMPMID26556804 Bellavia D; Cataliotti A; Clemenza F; Baravoglia CH; Luca A; Traina M; Gridelli B; Bertani T; Burnett JC; Scardulla C PLoS One 2015[]; 10 (11): � PMID26556804show ga Background and Aims: Compensatory renal hypertrophy following unilateral nephrectomy (UNX) occurs in the remaining kidney. However, the long-term cardiac adaptive process to UNX remains poorly defined in humans. Our goal was to characterize myocardial structure and function in living kidney donors (LKDs), approximately 12 years after UNX. Methods and Results: Cardiac function and structure in 15 Italian LKDs, at least 5 years after UNX (median time from donation = 8.4 years) was investigated and compared to those of age and sex matched U.S. citizens healthy controls (n = 15). Standard and speckle tracking echocardiography (STE) was performed in both LKDs and controls. Plasma angiotensin II, aldosterone, atrial natriuretic peptide (ANP), N terminus pro B-type natriuretic peptide (NT-proBNP), cyclic guanylyl monophosphate (cGMP), and amino-terminal peptide of procollagen III (PIIINP) were also collected. Median follow-up was 11.9 years. In LKDs, LV geometry and function by STE were similar to controls, wall thickness and volumes were within normal limits also by CMR. In LKDs, CMR was negative for myocardial fibrosis, but apical rotation and LV torsion obtained by STE were impaired as compared to controls (21.4 � 7.8 vs 32.7 � 8.9 degrees, p = 0.04). Serum creatinine and PIIINP levels were increased [1.1 (0.9?1.3) mg/dL, and 5.8 (5.4?7.6)] ?g/L, respectively), while urinary cGMP was reduced [270 (250?355) vs 581 (437?698) pmol/mL] in LKDs. No LKD developed cardiovascular or renal events during follow-up. Conclusions: Long-term kidney donors have no apparent structural myocardial abnormalities as assessed by contrast enhanced CMR. However, myocardial deformation of the apical segments, as well as apical rotation, and LV torsion are reduced. The concomitant increase in circulating PIIINP level is suggestive of fibrosis. Further studies, focused on US and EU patients are warranted to evaluate whether these early functional modifications will progress to a more compromised cardiac function and structure at a later time. �Long-Term Structural and Functional Myocardial Adaptations in Healthy (epmc).pdf DeepDyve Pubget Overpricing