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10.15252/embj.201591803 http://scihub22266oqcxt.onion/10.15252/embj.201591803 C4641532!4641532!26346275     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26346275&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26346275.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2015 ; 34 (21): 2671-85 Nephropedia Template TP {{tp|p=26346275|t=2015. Suppression of miR?199a maturation by HuR is crucial for hypoxia?induced glycolytic switch in hepatocellular carcinoma |pdf=|usr=}}{{26346275}} gab.com Text Suppression of miR 199a maturation by HuR is crucial for hypoxia induced glycolytic switch in hepatocellular carcinoma JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26346275 #FOAvip Glucose metabolic reprogramming is a hallmark of cancer. Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch is still incompletely understood. Here, we report that hypoxia potently induces the RNA?binding protein HuR to specifically bind primary miR?199a transcript to block miR?199a maturation in hepatocellular carcinoma (HCC) cells. We demonstrate that this hypoxia?suppressed miR?199a plays a decisive role in limiting glycolysis in HCC cells by targeting hexokinase?2 (Hk2) and pyruvate kinase?M2 (Pkm2). Furthermore, systemically delivered cholesterol?modified agomiR?199a inhibits [18F]?fluorodeoxyglucose uptake and attenuates tumor growth in HCC tumor?bearing mice. These data reveal a novel mechanism of reprogramming of cancer energy metabolism in which HuR suppresses miR?199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strategy that targets miR?199a to interrupt cancerous aerobic glycolysis. Twit Text FOAVip Suppression of miR 199a maturation by HuR is crucial for hypoxia induced glycolytic switch in hepatocellular carcinoma ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26346275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26346275 #FOAvip English Wikipedia <ref>{{Cite pmid|26346275}}</ref> Suppression of miR?199a maturation by HuR is crucial for hypoxia?induced glycolytic switch in hepatocellular carcinoma #MMPMID26346275 Zhang L; Lou J; Lu M; Gao C; Zhao S; Li B; Liang S; Li Y; Li D; Liu M EMBO J 2015[Nov]; 34 (21): 2671-85 PMID26346275show ga Glucose metabolic reprogramming is a hallmark of cancer. Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch is still incompletely understood. Here, we report that hypoxia potently induces the RNA?binding protein HuR to specifically bind primary miR?199a transcript to block miR?199a maturation in hepatocellular carcinoma (HCC) cells. We demonstrate that this hypoxia?suppressed miR?199a plays a decisive role in limiting glycolysis in HCC cells by targeting hexokinase?2 (Hk2) and pyruvate kinase?M2 (Pkm2). Furthermore, systemically delivered cholesterol?modified agomiR?199a inhibits [18F]?fluorodeoxyglucose uptake and attenuates tumor growth in HCC tumor?bearing mice. These data reveal a novel mechanism of reprogramming of cancer energy metabolism in which HuR suppresses miR?199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strategy that targets miR?199a to interrupt cancerous aerobic glycolysis. äSuppression of miR?199a maturation by HuR is crucial for hypoxia?induc(epmc).pdf DeepDyve Pubget Overpricing