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10.1074/jbc.M115.684274

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suck abstract from ncbi


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pmid26338710      J+Biol+Chem 2015 ; 290 (42): 25475-86
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  • Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells* #MMPMID26338710
  • Sasaki N; Itakura Y; Toyoda M
  • J Biol Chem 2015[Oct]; 290 (42): 25475-86 PMID26338710show ga
  • Background: The roles of gangliosides in senescent endothelial cells (ECs) were unknown.Results: Ganglioside GM1 increased on senescent and aged ECs. GM1 contributes to the impairment of insulin signaling in ECs.Conclusion: Increased GM1 with senescence and aging contributes to insulin resistance in ECs.Significance: GM1 is the first known contributor to insulin resistance in ECs.
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