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10.1074/jbc.M115.668293

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suck abstract from ncbi


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pmid26451045      J+Biol+Chem 2015 ; 290 (48): 28805-11
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  • The Polarized Effect of Intracellular Calcium on the Renal Epithelial Sodium Channel Occurs as a Result of Subcellular Calcium Signaling Domains Maintained by Mitochondria* #MMPMID26451045
  • Thai TL; Yu L; Galarza-Paez L; Wu MM; Lam HYC; Bao HF; Duke BJ; Al-Khalili O; Ma HP; Liu B; Eaton DC
  • J Biol Chem 2015[Nov]; 290 (48): 28805-11 PMID26451045show ga
  • Background: Mitochondria can sequester calcium and regulate signaling processes in epithelia.Results: Intracellular calcium regulates the renal epithelial sodium channel in a polarized fashion, and this polarity is dependent on mitochondrial calcium uptake.Conclusion: Mitochondria maintain calcium polarity in renal epithelia.Significance: Identifying subcellular calcium signaling domains in renal epithelia is essential to understanding ion channel regulation.
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