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10.1038/srep17541 http://scihub22266oqcxt.onion/10.1038/srep17541 C4668386!4668386!26632877     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26632877&cmd=llinks): Failed to open stream: HTTP request failed! 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When cells divide: Label-free multimodal spectral imaging for exploratory molecular investigation of living cells during cytokinesis |pdf=|usr=}}{{26632877}} gab.com Text When cells divide: Label-free multimodal spectral imaging for exploratory molecular investigation of living cells during cytokinesis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26632877 #FOAvip In vivo, molecular-level investigation of cytokinesis, the climax of the cell cycle, not only deepens our understanding of how life continues, but it will also open up new possibilities of diagnosis/prognosis of cancer cells. Although fluorescence-based methods have been widely employed to address this challenge, they require a fluorophore to be designed for a specific known biomolecule and introduced into the cell. Here, we present a label-free spectral imaging approach based on multivariate curve resolution analysis of Raman hyperspectral data that enables exploratory untargeted studies of mammalian cell cytokinesis. We derived intrinsic vibrational spectra and intracellular distributions of major biomolecular components (lipids and proteins) in dividing and nondividing human colon cancer cells. In addition, we discovered an unusual autofluorescent lipid component that appears predominantly in the vicinity of the cleavage furrow during cytokinesis. This autofluorescence signal could be utilized as an endogenous probe for monitoring and visualizing cytokinesis in vivo. Twit Text FOAVip When cells divide: Label-free multimodal spectral imaging for exploratory molecular investigation of living cells during cytokinesis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26632877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26632877 #FOAvip English Wikipedia <ref>{{Cite pmid|26632877}}</ref> When cells divide: Label-free multimodal spectral imaging for exploratory molecular investigation of living cells during cytokinesis #MMPMID26632877 Hsu JF; Hsieh PY; Hsu HY; Shigeto S Sci Rep 2015[]; 5 (ä): ä PMID26632877show ga In vivo, molecular-level investigation of cytokinesis, the climax of the cell cycle, not only deepens our understanding of how life continues, but it will also open up new possibilities of diagnosis/prognosis of cancer cells. Although fluorescence-based methods have been widely employed to address this challenge, they require a fluorophore to be designed for a specific known biomolecule and introduced into the cell. Here, we present a label-free spectral imaging approach based on multivariate curve resolution analysis of Raman hyperspectral data that enables exploratory untargeted studies of mammalian cell cytokinesis. We derived intrinsic vibrational spectra and intracellular distributions of major biomolecular components (lipids and proteins) in dividing and nondividing human colon cancer cells. In addition, we discovered an unusual autofluorescent lipid component that appears predominantly in the vicinity of the cleavage furrow during cytokinesis. This autofluorescence signal could be utilized as an endogenous probe for monitoring and visualizing cytokinesis in vivo. äWhen cells divide: Label-free multimodal spectral imaging for explorat(epmc).pdf DeepDyve Pubget Overpricing