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10.1289/ehp.1409199 http://scihub22266oqcxt.onion/10.1289/ehp.1409199 C4671234!4671234!25933419     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25933419&cmd=llinks): Failed to open stream: HTTP request failed! 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Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc |pdf=|usr=}}{{25933419}} gab.com Text Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc JO: Environ Health Perspect http://www.kidney.de/pget.php?&tw=1&pmid=25933419 #FOAvip Background: Humans are exposed to low-dose bisphenol A (BPA) through plastic consumer products and dental sealants containing BPA. Although a number of studies have investigated the mammary gland effects after high-dose BPA exposure, the study findings differ. Furthermore, there has been a lack of mechanistic studies. Objective: The objective of this study was to investigate the effect and the mechanism of low-dose BPA in mammary gland cells. Methods: We evaluated DNA damage following BPA exposure using the comet assay and immunofluorescence staining, and used cell counting and three-dimensional cultures to evaluate effects on proliferation. We examined the expressions of markers of DNA damage and cell-cycle regulators by immunoblotting and performed siRNA-mediated gene silencing to determine the role of c-Myc in regulating BPA?s effects. Results: Low-dose BPA significantly promoted DNA damage, up-regulated c-Myc and other cell-cycle regulatory proteins, and induced proliferation in parallel in estrogen receptor-? (ER?)-negative mammary cells. Silencing c-Myc diminished these BPA-induced cellular events, suggesting that c-Myc is essential for regulating effects of BPA on DNA damage and proliferation in mammary cells. Conclusions: Low-dose BPA exerted c-Myc?dependent genotoxic and mitogenic effects on ER?-negative mammary cells. These findings provide significant evidence of adverse effects of low-dose BPA on mammary cells. Citation: Pfeifer D, Chung YM, Hu MC. 2015. Effects of low-dose bisphenol A on DNA damage and proliferation of breast cells: the role of c-Myc. Environ Health Perspect 123:1271?1279; http://dx.doi.org/10.1289/ehp.1409199 Twit Text FOAVip Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc ????Environ Health Perspect http://www.kidney.de/pget.php?&tw=1&pmid=25933419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25933419 #FOAvip English Wikipedia <ref>{{Cite pmid|25933419}}</ref> Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc #MMPMID25933419 Pfeifer D; Chung YM; Hu MCT Environ Health Perspect 2015[Dec]; 123 (12): 1271-9 PMID25933419show ga Background: Humans are exposed to low-dose bisphenol A (BPA) through plastic consumer products and dental sealants containing BPA. Although a number of studies have investigated the mammary gland effects after high-dose BPA exposure, the study findings differ. Furthermore, there has been a lack of mechanistic studies. Objective: The objective of this study was to investigate the effect and the mechanism of low-dose BPA in mammary gland cells. Methods: We evaluated DNA damage following BPA exposure using the comet assay and immunofluorescence staining, and used cell counting and three-dimensional cultures to evaluate effects on proliferation. We examined the expressions of markers of DNA damage and cell-cycle regulators by immunoblotting and performed siRNA-mediated gene silencing to determine the role of c-Myc in regulating BPA?s effects. Results: Low-dose BPA significantly promoted DNA damage, up-regulated c-Myc and other cell-cycle regulatory proteins, and induced proliferation in parallel in estrogen receptor-? (ER?)-negative mammary cells. Silencing c-Myc diminished these BPA-induced cellular events, suggesting that c-Myc is essential for regulating effects of BPA on DNA damage and proliferation in mammary cells. Conclusions: Low-dose BPA exerted c-Myc?dependent genotoxic and mitogenic effects on ER?-negative mammary cells. These findings provide significant evidence of adverse effects of low-dose BPA on mammary cells. Citation: Pfeifer D, Chung YM, Hu MC. 2015. Effects of low-dose bisphenol A on DNA damage and proliferation of breast cells: the role of c-Myc. Environ Health Perspect 123:1271?1279; http://dx.doi.org/10.1289/ehp.1409199 äEffects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Bre(epmc).pdf DeepDyve Pubget Overpricing