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10.1002/art.39466 http://scihub22266oqcxt.onion/10.1002/art.39466 C4767657!4767657!26474155     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26474155&cmd=llinks): Failed to open stream: HTTP request failed! 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Myositis autoantibodies, clinical features, and environmental exposures at illness onset are associated with disease course in juvenile myositis |pdf=|usr=}}{{26474155}} gab.com Text Myositis autoantibodies, clinical features, and environmental exposures at illness onset are associated with disease course in juvenile myositis JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=26474155 #FOAvip Objective: To identify early factors associated with disease course in patients with juvenile idiopathic inflammatory myopathies (JIIM). Methods: Univariable and multivariable multinomial logistic regression analyses were performed in a large JIIM registry (n=365), including demographics, early clinical features, serum muscle enzyme levels, myositis autoantibodies, environmental exposures, and immunogenetic polymorphisms. Results: Multivariable associations with chronic or polycyclic courses compared to monocyclic included myositis-specific autoantibodies (multinomial odds ratio (M-OR) 4.2 and 2.8, respectively), myositis-associated autoantibodies (M-OR 4.8 and 3.5), and a documented infection within six months of illness onset (M-OR 2.5 and 4.7). A higher overall clinical symptom score at diagnosis was associated with chronic or monocyclic courses compared to polycyclic. Furthermore, a severe illness onset was associated with chronic compared to monocyclic or polycyclic courses (M-OR 2.1 and 2.6), while anti-p155/140 autoantibodies were associated with chronic or polycyclic courses compared to monocyclic (M-OR 3.9 and 2.3). Additional univariable associations of chronic compared to monocyclic course included photosensitivity, ?V-sign? or ?Shawl-sign? rashes, and cuticular overgrowth (OR 2.2?3.2). The mean and highest ultraviolet index in the month before diagnosis were associated with a chronic compared to polycyclic course in boys (OR 1.3 and 1.5), while residing in the Northwest was less frequently associated with a chronic course (OR 0.2). Conclusion: Myositis autoantibodies, in particular anti-p155/140, and a number of early clinical features and environmental exposures were associated with a chronic course in patients with JIIM. These findings suggest early factors can be identified that are associated with poorer outcomes in JIIM. Twit Text FOAVip Myositis autoantibodies, clinical features, and environmental exposures at illness onset are associated with disease course in juvenile myositis ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=26474155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26474155 #FOAvip English Wikipedia <ref>{{Cite pmid|26474155}}</ref> Myositis autoantibodies, clinical features, and environmental exposures at illness onset are associated with disease course in juvenile myositis #MMPMID26474155 Habers GEA; Huber AM; Mamyrova G; Targoff IN; O?Hanlon TP; Adams S; Pandey JP; Boonacker C; van Brussel M; Miller FW; van Royen-Kerkhof A; Rider LG Arthritis Rheumatol 2016[Mar]; 68 (3): 761-8 PMID26474155show ga Objective: To identify early factors associated with disease course in patients with juvenile idiopathic inflammatory myopathies (JIIM). Methods: Univariable and multivariable multinomial logistic regression analyses were performed in a large JIIM registry (n=365), including demographics, early clinical features, serum muscle enzyme levels, myositis autoantibodies, environmental exposures, and immunogenetic polymorphisms. Results: Multivariable associations with chronic or polycyclic courses compared to monocyclic included myositis-specific autoantibodies (multinomial odds ratio (M-OR) 4.2 and 2.8, respectively), myositis-associated autoantibodies (M-OR 4.8 and 3.5), and a documented infection within six months of illness onset (M-OR 2.5 and 4.7). A higher overall clinical symptom score at diagnosis was associated with chronic or monocyclic courses compared to polycyclic. Furthermore, a severe illness onset was associated with chronic compared to monocyclic or polycyclic courses (M-OR 2.1 and 2.6), while anti-p155/140 autoantibodies were associated with chronic or polycyclic courses compared to monocyclic (M-OR 3.9 and 2.3). Additional univariable associations of chronic compared to monocyclic course included photosensitivity, ?V-sign? or ?Shawl-sign? rashes, and cuticular overgrowth (OR 2.2?3.2). The mean and highest ultraviolet index in the month before diagnosis were associated with a chronic compared to polycyclic course in boys (OR 1.3 and 1.5), while residing in the Northwest was less frequently associated with a chronic course (OR 0.2). Conclusion: Myositis autoantibodies, in particular anti-p155/140, and a number of early clinical features and environmental exposures were associated with a chronic course in patients with JIIM. These findings suggest early factors can be identified that are associated with poorer outcomes in JIIM. äMyositis autoantibodies, clinical features, and environmental exposure(epmc).pdf DeepDyve Pubget Overpricing