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10.1158/0008-5472.CAN-15-0204 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-0204 C4794356!4794356!26719537     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26719537&cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the pre-metastatic niche |pdf=|usr=}}{{26719537}} gab.com Text Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the pre-metastatic niche JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26719537 #FOAvip Metastatic tumors have been shown to establish microenvironments in distant tissues that are permissive to disseminated tumor cells. Hematopoietic cells contribute to this microenvironment, yet the precise initiating events responsible for establishing the pre-metastatic niche remain unclear. Here, we tracked the developmental fate of hematopoietic stem and progenitor cells (HSPCs) in tumor-bearing mice. We show that a distant primary tumor drives the expansion of HSPCs within the bone marrow and their mobilization to the bloodstream. Treatment of purified HSPCs cultured ex vivo with tumor-conditioned media induced their proliferation as well as their differentiation into immunosuppressive myeloid cells. We furthered tracked purified HSPCs in vivo and found they differentiated into myeloid-derived suppressor cells (MDSCs) in early metastatic sites of tumor-bearing mice. The number of CD11b+Ly6g+ cells in metastatic sites was significantly increased by HSPC mobilization and decreased if tumor-mediated mobilization was inhibited. Moreover, pharmacological mobilization of HSPCs increased metastasis, whereas depletion of Gr1+ cells abrogated the metastasis-promoting effects of HSPC mobilization. Finally, we detected elevated levels of HSPCs in the circulation of newly diagnosed cancer patients, which correlated with increased risk for metastatic progression. Taken together, our results highlight bone marrow activation as one of the earliest steps of the metastatic process and identify circulating HSPCs as potential clinical indicators of metastatic niche formation. Twit Text FOAVip Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the pre-metastatic niche ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26719537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26719537 #FOAvip English Wikipedia <ref>{{Cite pmid|26719537}}</ref> Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the pre-metastatic niche #MMPMID26719537 Giles AJ; Reid CM; Evans JD; Murgai M; Vicioso Y; Highfill SL; Kasai M; Vahdat L; Mackall CL; Lyden D; Wexler L; Kaplan RN Cancer Res 2016[Mar]; 76 (6): 1335-47 PMID26719537show ga Metastatic tumors have been shown to establish microenvironments in distant tissues that are permissive to disseminated tumor cells. Hematopoietic cells contribute to this microenvironment, yet the precise initiating events responsible for establishing the pre-metastatic niche remain unclear. Here, we tracked the developmental fate of hematopoietic stem and progenitor cells (HSPCs) in tumor-bearing mice. We show that a distant primary tumor drives the expansion of HSPCs within the bone marrow and their mobilization to the bloodstream. Treatment of purified HSPCs cultured ex vivo with tumor-conditioned media induced their proliferation as well as their differentiation into immunosuppressive myeloid cells. We furthered tracked purified HSPCs in vivo and found they differentiated into myeloid-derived suppressor cells (MDSCs) in early metastatic sites of tumor-bearing mice. The number of CD11b+Ly6g+ cells in metastatic sites was significantly increased by HSPC mobilization and decreased if tumor-mediated mobilization was inhibited. Moreover, pharmacological mobilization of HSPCs increased metastasis, whereas depletion of Gr1+ cells abrogated the metastasis-promoting effects of HSPC mobilization. Finally, we detected elevated levels of HSPCs in the circulation of newly diagnosed cancer patients, which correlated with increased risk for metastatic progression. Taken together, our results highlight bone marrow activation as one of the earliest steps of the metastatic process and identify circulating HSPCs as potential clinical indicators of metastatic niche formation. äActivation of hematopoietic stem/progenitor cells promotes immunosuppr(epmc).pdf DeepDyve Pubget Overpricing