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10.1091/mbc.E15-08-0569

http://scihub22266oqcxt.onion/10.1091/mbc.E15-08-0569
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C4814216!4814216!26864623
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suck abstract from ncbi


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pmid26864623      Mol+Biol+Cell 2016 ; 27 (7): 1069-84
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  • LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion #MMPMID26864623
  • Konen J; Wilkinson S; Lee B; Fu H; Zhou W; Jiang Y; Marcus AI
  • Mol Biol Cell 2016[Apr]; 27 (7): 1069-84 PMID26864623show ga
  • Farnesylation of the LKB1 C-terminal domain promotes mesenchymal polarization and directional persistence during three-dimensional invasion by activating the Rho-GTPase RhoA in a kinase-independent manner. Conversely, LKB1 kinase activity represses FAK activity through MARK1, which subsequently inhibits downstream collagen remodeling during invasion.
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