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10.1038/srep23821 http://scihub22266oqcxt.onion/10.1038/srep23821 C4814874!4814874!27030642     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27030642.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27030642|t=2016. CD4+ and CD8+ TCR? repertoires possess different potentials to generate extraordinarily high-avidity T cells |pdf=|usr=}}{{27030642}} gab.com Text CD4+ and CD8+ TCR repertoires possess different potentials to generate extraordinarily high-avidity T cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27030642 #FOAvip Recent high throughput sequencing analysis has revealed that the TCR? repertoire is largely different between CD8+ and CD4+ T cells. Here, we show that the transduction of SIG35?, the public chain-centric HLA-A*02:01(A2)/MART127?35 TCR? hemichain, conferred A2/MART127?35 reactivity to a substantial subset of both CD8+ and CD4+ T cells regardless of their HLA?A2 positivity. T cells individually reconstituted with SIG35? and different A2/MART127?35 TCR? genes isolated from CD4+ or CD8+ T cells exhibited a wide range of avidity. Surprisingly, approximately half of the A2/MART127?35 TCRs derived from CD4+ T cells, but none from CD8+ T cells, were stained by A2/MART127?35 monomer and possessed broader cross-reactivity. Our results suggest that the differences in the primary structure of peripheral CD4+ and CD8+ TCR? repertoire indeed result in the differences in their ability to form extraordinarily high avidity T cells which would otherwise have been deleted by central tolerance. Twit Text FOAVip CD4+ and CD8+ TCR repertoires possess different potentials to generate extraordinarily high-avidity T cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27030642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27030642 #FOAvip English Wikipedia <ref>{{Cite pmid|27030642}}</ref> CD4+ and CD8+ TCR? repertoires possess different potentials to generate extraordinarily high-avidity T cells #MMPMID27030642 Nakatsugawa M; Rahman MA; Yamashita Y; Ochi T; Wnuk P; Tanaka S; Chamoto K; Kagoya Y; Saso K; Guo T; Anczurowski M; Butler MO; Hirano N Sci Rep 2016[]; 6 (ä): ä PMID27030642show ga Recent high throughput sequencing analysis has revealed that the TCR? repertoire is largely different between CD8+ and CD4+ T cells. Here, we show that the transduction of SIG35?, the public chain-centric HLA-A*02:01(A2)/MART127?35 TCR? hemichain, conferred A2/MART127?35 reactivity to a substantial subset of both CD8+ and CD4+ T cells regardless of their HLA?A2 positivity. T cells individually reconstituted with SIG35? and different A2/MART127?35 TCR? genes isolated from CD4+ or CD8+ T cells exhibited a wide range of avidity. Surprisingly, approximately half of the A2/MART127?35 TCRs derived from CD4+ T cells, but none from CD8+ T cells, were stained by A2/MART127?35 monomer and possessed broader cross-reactivity. Our results suggest that the differences in the primary structure of peripheral CD4+ and CD8+ TCR? repertoire indeed result in the differences in their ability to form extraordinarily high avidity T cells which would otherwise have been deleted by central tolerance. äCD4+ and CD8+ TCR? repertoires possess different potentials to generat(epmc).pdf DeepDyve Pubget Overpricing