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10.1073/pnas.1602264113

http://scihub22266oqcxt.onion/10.1073/pnas.1602264113
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suck abstract from ncbi


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pmid26976564      Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (13): E1872-80
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  • Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition #MMPMID26976564
  • Chaudhuri D; Artiga DJ; Abiria SA; Clapham DE
  • Proc Natl Acad Sci U S A 2016[Mar]; 113 (13): E1872-80 PMID26976564show ga
  • Cells injured by a variety of stressors feature a form of mitochondrial dysfunction termed the permeability transition. During this process, mitochondria swell and become disrupted, ultimately leading to cell death. In excitable cells such as cardiomyocytes or neurons, such injury is often triggered by calcium overload. By screening Drosophila cells, we have found a protein, mitochondrial calcium uniporter regulator 1 (MCUR1), that appears to regulate the amount of calcium required to induce the permeability transition. Modulating the function of this protein acutely may prove beneficial in limiting tissue damage during diseases that feature calcium overload.
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