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10.1038/cddis.2016.62 http://scihub22266oqcxt.onion/10.1038/cddis.2016.62 C4823961!4823961!27010856     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27010856.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2016 ; 7 (3): e2155- Nephropedia Template TP {{tp|p=27010856|t=2016. Downregulation of renal tubular Wnt/?-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy |pdf=|usr=}}{{27010856}} gab.com Text Downregulation of renal tubular Wnt/ -catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27010856 #FOAvip Studies on the role of Wnt/?-catenin signaling in different forms of kidney disease have yielded discrepant results. Here, we report the biphasic change of renal ?-catenin expression in mice with overload proteinuria in which ?-catenin was upregulated at the early stage (4 weeks after disease induction) but abrogated at the late phase (8 weeks). Acute albuminuria was observed at 1 week after bovine serum albumin injection, followed by partial remission at 4 weeks that coincided with overexpression of renal tubular ?-catenin. Interestingly, a rebound in albuminuria at 8 weeks was accompanied by downregulated tubular ?-catenin expression and heightened tubular apoptosis. In addition, there was an inverse relationship between Dickkopf-3 (Dkk-3) and renal tubular ?-catenin expression at these time points. In vitro, a similar trend in ?-catenin expression was observed in human kidney-2 (HK-2) cells with acute (upregulation) and prolonged (downregulation) exposure to albumin. Induction of a proapoptotic phenotype by albumin was significantly enhanced by silencing ?-catenin in HK-2 cells. Finally, Dkk-3 expression and secretion was increased after prolonged exposure to albumin, leading to the suppression of intracellular ?-catenin signaling pathway. The effect of Dkk-3 on ?-catenin signaling was confirmed by incubation with exogenous Dkk-3 in HK-2 cells. Taken together, these data suggest that downregulation of tubular ?-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis. Twit Text FOAVip Downregulation of renal tubular Wnt/ -catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27010856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27010856 #FOAvip English Wikipedia <ref>{{Cite pmid|27010856}}</ref> Downregulation of renal tubular Wnt/?-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy #MMPMID27010856 Wong DWL; Yiu WH; Wu HJ; Li RX; Liu Y; Chan KW; Leung JCK; Chan LYY; Lai KN; Tang SCW Cell Death Dis 2016[Mar]; 7 (3): e2155- PMID27010856show ga Studies on the role of Wnt/?-catenin signaling in different forms of kidney disease have yielded discrepant results. Here, we report the biphasic change of renal ?-catenin expression in mice with overload proteinuria in which ?-catenin was upregulated at the early stage (4 weeks after disease induction) but abrogated at the late phase (8 weeks). Acute albuminuria was observed at 1 week after bovine serum albumin injection, followed by partial remission at 4 weeks that coincided with overexpression of renal tubular ?-catenin. Interestingly, a rebound in albuminuria at 8 weeks was accompanied by downregulated tubular ?-catenin expression and heightened tubular apoptosis. In addition, there was an inverse relationship between Dickkopf-3 (Dkk-3) and renal tubular ?-catenin expression at these time points. In vitro, a similar trend in ?-catenin expression was observed in human kidney-2 (HK-2) cells with acute (upregulation) and prolonged (downregulation) exposure to albumin. Induction of a proapoptotic phenotype by albumin was significantly enhanced by silencing ?-catenin in HK-2 cells. Finally, Dkk-3 expression and secretion was increased after prolonged exposure to albumin, leading to the suppression of intracellular ?-catenin signaling pathway. The effect of Dkk-3 on ?-catenin signaling was confirmed by incubation with exogenous Dkk-3 in HK-2 cells. Taken together, these data suggest that downregulation of tubular ?-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis. äDownregulation of renal tubular Wnt/?-catenin signaling by Dickkopf-3 (epmc).pdf DeepDyve Pubget Overpricing