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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury What We Know and What We Need to Know: Findings from a National Working Group #MMPMID27002812
Wickwire EM; Williams SG; Roth T; Capaldi VF; Jaffe M; Moline M; Motamedi GK; Morgan GW; Mysliwiec V; Germain A; Pazdan RM; Ferziger R; Balkin TJ; MacDonald ME; Macek TA; Yochelson MR; Scharf SM; Lettieri CJ
Neurotherapeutics 2016[Apr]; 13 (2): 403-17 PMID27002812show ga
Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-016-0429-3) contains supplementary material, which is available to authorized users.