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10.1038/cdd.2015.152 http://scihub22266oqcxt.onion/10.1038/cdd.2015.152 C4832106!4832106!26679521     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26679521&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26679521.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Differ 2016 ; 23 (5): 876-88 Nephropedia Template TP {{tp|p=26679521|t=2016. The ubiquitin ligase Smurf2 suppresses TGF?-induced epithelial?mesenchymal transition in a sumoylation-regulated manner |pdf=|usr=}}{{26679521}} gab.com Text The ubiquitin ligase Smurf2 suppresses TGF -induced epithelial mesenchymal transition in a sumoylation-regulated manner JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26679521 #FOAvip Epithelial?mesenchymal transition (EMT) is a fundamental cellular process in epithelial tissue development, and can be reactivated in cancer contributing to tumor invasiveness and metastasis. The cytokine transforming growth factor-? (TGF?) is a key inducer of EMT, but the mechanisms that regulate TGF?-induced EMT remain incompletely understood. Here, we report that knockdown of the ubiquitin ligase Smurf2 promotes the ability of TGF? to induce EMT in a three-dimensional cell culture model of NMuMG mammary epithelial cells. In other studies, we identify Smurf2 as a target of the small ubiquitin like modifier (SUMO) pathway. We find that the SUMO-E2 conjugating enzyme Ubc9 and the SUMO E3 ligase PIAS3 associate with Smurf2 and promote its sumoylation at the distinct sites of Lysines 26 and 369. The sumoylation of Smurf2 enhances its ability to induce the degradation of the TGF? receptor and thereby suppresses EMT in NMuMG cells. Collectively, our data reveal that Smurf2 acts in a sumoylation-regulated manner to suppress TGF?-induced EMT. These findings have significant implications for our understanding of epithelial tissue development and cancer. Twit Text FOAVip The ubiquitin ligase Smurf2 suppresses TGF -induced epithelial mesenchymal transition in a sumoylation-regulated manner ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26679521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26679521 #FOAvip English Wikipedia <ref>{{Cite pmid|26679521}}</ref> The ubiquitin ligase Smurf2 suppresses TGF?-induced epithelial?mesenchymal transition in a sumoylation-regulated manner #MMPMID26679521 Chandhoke AS; Karve K; Dadakhujaev S; Netherton S; Deng L; Bonni S Cell Death Differ 2016[May]; 23 (5): 876-88 PMID26679521show ga Epithelial?mesenchymal transition (EMT) is a fundamental cellular process in epithelial tissue development, and can be reactivated in cancer contributing to tumor invasiveness and metastasis. The cytokine transforming growth factor-? (TGF?) is a key inducer of EMT, but the mechanisms that regulate TGF?-induced EMT remain incompletely understood. Here, we report that knockdown of the ubiquitin ligase Smurf2 promotes the ability of TGF? to induce EMT in a three-dimensional cell culture model of NMuMG mammary epithelial cells. In other studies, we identify Smurf2 as a target of the small ubiquitin like modifier (SUMO) pathway. We find that the SUMO-E2 conjugating enzyme Ubc9 and the SUMO E3 ligase PIAS3 associate with Smurf2 and promote its sumoylation at the distinct sites of Lysines 26 and 369. The sumoylation of Smurf2 enhances its ability to induce the degradation of the TGF? receptor and thereby suppresses EMT in NMuMG cells. Collectively, our data reveal that Smurf2 acts in a sumoylation-regulated manner to suppress TGF?-induced EMT. These findings have significant implications for our understanding of epithelial tissue development and cancer. äThe ubiquitin ligase Smurf2 suppresses TGF?-induced epithelial?mesench(epmc).pdf DeepDyve Pubget Overpricing