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10.1002/eji.201545995 http://scihub22266oqcxt.onion/10.1002/eji.201545995 C4832341!4832341!26694097     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26694097.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2016 ; 46 (4): 846-56 Nephropedia Template TP {{tp|p=26694097|t=2016. Dynamic spatio?temporal contribution of single ?5t+ cortical epithelial precursors to the thymus medulla |pdf=|usr=}}{{26694097}} gab.com Text Dynamic spatio temporal contribution of single 5t+ cortical epithelial precursors to the thymus medulla JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26694097 #FOAvip Intrathymic T?cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit ?5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that ?5t+ TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage?tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual ?5t+ cortical progenitors located at the cortico?medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio?temporal dynamics that control the growth of the thymic medulla. Twit Text FOAVip Dynamic spatio temporal contribution of single 5t+ cortical epithelial precursors to the thymus medulla ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26694097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26694097 #FOAvip English Wikipedia <ref>{{Cite pmid|26694097}}</ref> Dynamic spatio?temporal contribution of single ?5t+ cortical epithelial precursors to the thymus medulla #MMPMID26694097 Mayer CE; ?uklys S; Zhanybekova S; Ohigashi I; Teh H; Sansom SN; Shikama?Dorn N; Hafen K; Macaulay IC; Deadman ME; Ponting CP; Takahama Y; Holländer GA Eur J Immunol 2016[Apr]; 46 (4): 846-56 PMID26694097show ga Intrathymic T?cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit ?5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that ?5t+ TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage?tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual ?5t+ cortical progenitors located at the cortico?medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio?temporal dynamics that control the growth of the thymic medulla. äDynamic spatio?temporal contribution of single ?5t+ cortical epithelia(epmc).pdf DeepDyve Pubget Overpricing