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Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor-?1 in streptozotocin-induced diabetic rat model |pdf=|usr=}}{{27114796}} gab.com Text Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor- 1 in streptozotocin-induced diabetic rat model JO: Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=27114796 #FOAvip Objective(s):: Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-? (TGF-?). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGF?1 modulator. In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromodulin on TGF-?1 expression on diabetic nephropathy were assessed. Materials and Methods:: Forty-eight Sprague-Dawley rats were divided into 4 groups: STZ-induced diabetic rats (diabetic-control), fibromodulin adenovirus vector treated STZ rats (Ad- fibromodulin), and Ad-lacZ-treated STZ rats (Ad-lacZ), and vehicle control (PBS-control). At 10 weeks after STZ treatment, we measured urinary albumin excretion (UAE), urine creatinine was measured by Jaffe method. We also measured kidney TGF-?1 levels by reverse transcription polymerase chain reaction and Real-time PCR. Results:: Urine albumin to creatinine ratio or UAE level were listed in four groups. UAE difference between healthy and diabetic rats in all three groups were significant (P?0.005) and between the control group and treated groups were not significant. Our results indicated that TGF-?1gene expression in diabetic rats were increased and difference between normal group and diabetic group were significant (P?0.001). Fibromodulin gene transfection mediated by a recombinant adenovirus decreased TGF-?1 level in STZ-induced diabetic rats and TGF-?1 mRNA in diabetic kidney were reduced 2 weeks after Ad-fibromodulin injection. Conclusion:: Intraperitoneal injection of adenoviral vectors expressing fibromodulin reduced TGF-?1 level in diabetic rat models. The molecular mechanisms involved in this process require further study. Twit Text FOAVip Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor- 1 in streptozotocin-induced diabetic rat model ????Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=27114796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27114796 #FOAvip English Wikipedia <ref>{{Cite pmid|27114796}}</ref> Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor-?1 in streptozotocin-induced diabetic rat model #MMPMID27114796 Jazi MF; Biglari A; Mazloomzadeh S; Kingston P; Ramazani A; Bazzaz JT; Eskandari M Iran J Basic Med Sci 2016[Mar]; 19 (3): 265-71 PMID27114796show ga Objective(s):: Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-? (TGF-?). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGF?1 modulator. In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromodulin on TGF-?1 expression on diabetic nephropathy were assessed. Materials and Methods:: Forty-eight Sprague-Dawley rats were divided into 4 groups: STZ-induced diabetic rats (diabetic-control), fibromodulin adenovirus vector treated STZ rats (Ad- fibromodulin), and Ad-lacZ-treated STZ rats (Ad-lacZ), and vehicle control (PBS-control). At 10 weeks after STZ treatment, we measured urinary albumin excretion (UAE), urine creatinine was measured by Jaffe method. We also measured kidney TGF-?1 levels by reverse transcription polymerase chain reaction and Real-time PCR. Results:: Urine albumin to creatinine ratio or UAE level were listed in four groups. UAE difference between healthy and diabetic rats in all three groups were significant (P?0.005) and between the control group and treated groups were not significant. Our results indicated that TGF-?1gene expression in diabetic rats were increased and difference between normal group and diabetic group were significant (P?0.001). Fibromodulin gene transfection mediated by a recombinant adenovirus decreased TGF-?1 level in STZ-induced diabetic rats and TGF-?1 mRNA in diabetic kidney were reduced 2 weeks after Ad-fibromodulin injection. Conclusion:: Intraperitoneal injection of adenoviral vectors expressing fibromodulin reduced TGF-?1 level in diabetic rat models. The molecular mechanisms involved in this process require further study. äRecombinant fibromodulin has therapeutic effects on diabetic nephropat(epmc).pdf DeepDyve Pubget Overpricing