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10.1111/cei.12768 http://scihub22266oqcxt.onion/10.1111/cei.12768 C4837234!4837234!26756979     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26756979&cmd=llinks): Failed to open stream: HTTP request failed! 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Immunometabolic biomarkers of inflammation in Behçet s disease: relationship with epidemiological profile, disease activity and therapeutic regimens |pdf=|usr=}}{{26756979}} gab.com Text Immunometabolic biomarkers of inflammation in Behçet s disease: relationship with epidemiological profile, disease activity and therapeutic regimens JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26756979 #FOAvip Behcet's disease (BD) is a systemic inflammatory disease with a still unclear pathogenesis. Although several inflammatory molecules have been studied, current biomarkers are largely insensitive in BD and unable to predict disease progression and response to treatment. Our primary aim was to explore serum levels of soluble CD40 L (sCD40L), soluble intracellular adhesion molecule (sICAM?1), monocyte chemoattractant protein?1 (MCP?1), myeloperoxidase (MPO), leptin, resistin, osteoprotegerin (OPG), soluble type 1 tumour necrosis factor receptor (sTNFR), interleukin (IL)?6 and serum amyloid A (SAA) serum concentration in a cohort of 27 BD patients. The secondary aim was to evaluate potential correlations between the putative circulating biomarkers, demographic profile of patients, the status of disease activity, the specific organ involvement at the time of sample collection and different therapeutic regimens. Serum concentrations of sTNFR (P = 0·008), leptin (P = 0·0011), sCD40L (P < 0·0001) and IL?6 (P = 0·0154) were significantly higher in BD patients than in HC, while no difference was found in MCP?1, MPO and resistin serum levels. Moreover, we observed significantly higher sTNFR serum concentrations in BD patients presenting inactive disease than HC (P = 0·0108). A correlation between sTNFR and age was also found, with higher levels in patients over 40 years than HC (P = 0·0329). Although further research is warranted to elucidate the role of circulating biomarkers, some of that may contribute to the understanding of the physiopathology processes underlying BD activity and damage as well as to provide useful tools for prognostic purposes and a personalized treatment approach. Twit Text FOAVip Immunometabolic biomarkers of inflammation in Behçet s disease: relationship with epidemiological profile, disease activity and therapeutic regimens ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26756979 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26756979 #FOAvip English Wikipedia <ref>{{Cite pmid|26756979}}</ref> Immunometabolic biomarkers of inflammation in Behçet s disease: relationship with epidemiological profile, disease activity and therapeutic regimens #MMPMID26756979 Cantarini L; Pucino V; Vitale A; Talarico R; M. Lucherini O; Magnotti F; De Rosa V; Galgani M; Alviggi C; Marone G; Galeazzi M; Matarese G Clin Exp Immunol 2016[May]; 184 (2): 197-207 PMID26756979show ga Behcet's disease (BD) is a systemic inflammatory disease with a still unclear pathogenesis. Although several inflammatory molecules have been studied, current biomarkers are largely insensitive in BD and unable to predict disease progression and response to treatment. Our primary aim was to explore serum levels of soluble CD40 L (sCD40L), soluble intracellular adhesion molecule (sICAM?1), monocyte chemoattractant protein?1 (MCP?1), myeloperoxidase (MPO), leptin, resistin, osteoprotegerin (OPG), soluble type 1 tumour necrosis factor receptor (sTNFR), interleukin (IL)?6 and serum amyloid A (SAA) serum concentration in a cohort of 27 BD patients. The secondary aim was to evaluate potential correlations between the putative circulating biomarkers, demographic profile of patients, the status of disease activity, the specific organ involvement at the time of sample collection and different therapeutic regimens. Serum concentrations of sTNFR (P = 0·008), leptin (P = 0·0011), sCD40L (P < 0·0001) and IL?6 (P = 0·0154) were significantly higher in BD patients than in HC, while no difference was found in MCP?1, MPO and resistin serum levels. Moreover, we observed significantly higher sTNFR serum concentrations in BD patients presenting inactive disease than HC (P = 0·0108). A correlation between sTNFR and age was also found, with higher levels in patients over 40 years than HC (P = 0·0329). Although further research is warranted to elucidate the role of circulating biomarkers, some of that may contribute to the understanding of the physiopathology processes underlying BD activity and damage as well as to provide useful tools for prognostic purposes and a personalized treatment approach. äImmunometabolic biomarkers of inflammation in Behçet s disease: relati(epmc).pdf DeepDyve Pubget Overpricing