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10.1038/ni.3333 http://scihub22266oqcxt.onion/10.1038/ni.3333 C4862588!4862588!26642356     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26642356.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (3): 250-8 Nephropedia Template TP {{tp|p=26642356|t=2016. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component |pdf=|usr=}}{{26642356}} gab.com Text NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26642356 #FOAvip The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines including IL-1? and IL-18. We show that NLRP3 inflammasome activation is restricted to interphase of the cell cycle by NEK7, a serine/threonine kinase previously implicated in mitosis. NLRP3 inflammasome activation requires NEK7, which binds to the NLRP3 leucine-rich repeat domain in a kinase-independent manner downstream from the induction of mitochondrial ROS. This interaction is necessary for NLRP3-ASC complex formation, ASC oligomerization, and caspase-1 activation. NEK7 promotes the NLRP3-dependent cellular inflammatory response to intraperitoneal monosodium urate challenge, and the development of experimental autoimmune encephalitis in mice. Our findings suggest NEK7 serves as a cellular switch that enforces mutual exclusivity between the inflammasome response and cell division. Twit Text FOAVip NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26642356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26642356 #FOAvip English Wikipedia <ref>{{Cite pmid|26642356}}</ref> NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component #MMPMID26642356 Shi H; Wang Y; Li X; Zhan X; Tan M; Fina M; Su L; Pratt D; Bu CH; Hildebrand S; Lyon S; Scott L; Quan J; Sun Q; Russell J; Arnett S; Jurek P; Chen D; Kravchenko VV; Mathison JC; Moresco EMY; Monson NL; Ulevitch RJ; Beutler B Nat Immunol 2016[Mar]; 17 (3): 250-8 PMID26642356show ga The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines including IL-1? and IL-18. We show that NLRP3 inflammasome activation is restricted to interphase of the cell cycle by NEK7, a serine/threonine kinase previously implicated in mitosis. NLRP3 inflammasome activation requires NEK7, which binds to the NLRP3 leucine-rich repeat domain in a kinase-independent manner downstream from the induction of mitochondrial ROS. This interaction is necessary for NLRP3-ASC complex formation, ASC oligomerization, and caspase-1 activation. NEK7 promotes the NLRP3-dependent cellular inflammatory response to intraperitoneal monosodium urate challenge, and the development of experimental autoimmune encephalitis in mice. Our findings suggest NEK7 serves as a cellular switch that enforces mutual exclusivity between the inflammasome response and cell division. äNLRP3 activation and mitosis are mutually exclusive events coordinated(epmc).pdf DeepDyve Pubget Overpricing