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10.4049/jimmunol.1502614

http://scihub22266oqcxt.onion/10.4049/jimmunol.1502614
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C4868662!4868662!27016608
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suck abstract from ncbi


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pmid27016608      J+Immunol 2016 ; 196 (9): 3542-6
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  • Integrin alpha-4 is required for regulatory B cell control of experimental autoimmune encephalomyelitis #MMPMID27016608
  • Glatigny S; Wagner CA; Bettelli E
  • J Immunol 2016[May]; 196 (9): 3542-6 PMID27016608show ga
  • The neutralization of alpha-4 integrin (Itga4) is currently used as treatment in multiple sclerosis. While most studies focused on its function on lymphocyte migration to the central nervous system, we have uncovered the importance of Itga4 expression on B cells for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology. Our study underscores the importance of looking at the dual role of B cells in CNS autoimmunity and provides important perspectives regarding the efficacy and side effects associated with Itga4 neutralization and other B cell targeting therapies.
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