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10.1007/s13238-012-2937-1 http://scihub22266oqcxt.onion/10.1007/s13238-012-2937-1 C4875393!4875393!22773341     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22773341.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Protein+Cell 2012 ; 3 (7): 521-5 Nephropedia Template TP {{tp|p=22773341|t=2012. Ultra-structural study of insulin granules in pancreatic ?-cells of db/db mouse by scanning transmission electron microscopy tomography |pdf=|usr=}}{{22773341}} gab.com Text Ultra-structural study of insulin granules in pancreatic -cells of db/db mouse by scanning transmission electron microscopy tomography JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=22773341 #FOAvip Insulin granule trafficking is a key step in the secretion of glucose-stimulated insulin from pancreatic ?-cells. The main feature of type 2 diabetes (T2D) is the failure of pancreatic ?-cells to secrete sufficient amounts of insulin to maintain normal blood glucose levels. In this work, we developed and applied tomography based on scanning transmission electron microscopy (STEM) to image intact insulin granules in the ?-cells of mouse pancreatic islets. Using three-dimensional (3D) reconstruction, we found decreases in both the number and the grey level of insulin granules in db/db mouse pancreatic ?-cells. Moreover, insulin granules were closer to the plasma membrane in diabetic ?-cells than in control cells. Thus, 3D ultra-structural tomography may provide new insights into the pathology of insulin secretion in T2D.Electronic Supplementary Material: The online version of this article (doi:10.1007/s13238-012-2937-1 contains supplementary material, which is available to authorized users. Twit Text FOAVip Ultra-structural study of insulin granules in pancreatic -cells of db/db mouse by scanning transmission electron microscopy tomography ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=22773341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22773341 #FOAvip English Wikipedia <ref>{{Cite pmid|22773341}}</ref> Ultra-structural study of insulin granules in pancreatic ?-cells of db/db mouse by scanning transmission electron microscopy tomography #MMPMID22773341 Xue Y; Zhao W; Du W; Zhang X; Ji G; Ying W; Xu T Protein Cell 2012[Jul]; 3 (7): 521-5 PMID22773341show ga Insulin granule trafficking is a key step in the secretion of glucose-stimulated insulin from pancreatic ?-cells. The main feature of type 2 diabetes (T2D) is the failure of pancreatic ?-cells to secrete sufficient amounts of insulin to maintain normal blood glucose levels. In this work, we developed and applied tomography based on scanning transmission electron microscopy (STEM) to image intact insulin granules in the ?-cells of mouse pancreatic islets. Using three-dimensional (3D) reconstruction, we found decreases in both the number and the grey level of insulin granules in db/db mouse pancreatic ?-cells. Moreover, insulin granules were closer to the plasma membrane in diabetic ?-cells than in control cells. Thus, 3D ultra-structural tomography may provide new insights into the pathology of insulin secretion in T2D.Electronic Supplementary Material: The online version of this article (doi:10.1007/s13238-012-2937-1 contains supplementary material, which is available to authorized users. äUltra-structural study of insulin granules in pancreatic ?-cells of db(epmc).pdf DeepDyve Pubget Overpricing