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10.1038/nn.4054

http://scihub22266oqcxt.onion/10.1038/nn.4054
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C4878404!4878404!26120963
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suck abstract from ncbi


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pmid26120963      Nat+Neurosci 2015 ; 18 (8): 1077-80
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  • Nuclear pore complex remodeling by p75NTR cleavage controls TGF-? signaling and astrocyte functions #MMPMID26120963
  • Schachtrup C; Ryu JK; Mammadzada K; Khan AS; Carlton PM; Perez A; Christian F; Le Moan N; Vagena E; Baeza-Raja B; Rafalski V; Chan JP; Nitschke R; Houslay MD; Ellisman MH; Wyss-Coray T; Palop JJ; Akassoglou K
  • Nat Neurosci 2015[Aug]; 18 (8): 1077-80 PMID26120963show ga
  • Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75NTR) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-? signaling. The cleaved p75NTR interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75NTR controls astrocyte-neuronal communication in response to profibrotic factors.
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