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10.1242/jcs.180703 http://scihub22266oqcxt.onion/10.1242/jcs.180703 C4893800!4893800!26989131     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26989131&cmd=llinks): Failed to open stream: HTTP request failed! 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Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body |pdf=|usr=}}{{26989131}} gab.com Text Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26989131 #FOAvip Epiboly is a morphogenetic process that is employed in the surface ectoderm of anamniotes during gastrulation to cover the entire embryo. We propose here that mammals also utilise this process to expand the epidermis and enclose the body cavity and spinal cord with a protective surface covering. Our data supports a model whereby epidermal spreading is driven by the primary establishment of the epidermal basal progenitor monolayer through radial cell intercalation of a multi-layered epithelium towards the basal lamina. By using a suspension organotypic culture strategy, we find that this process is fibronectin-dependent and autonomous to the skin. The radial cell rearrangements that drive epidermal spreading also require ROCK activity but are driven by cell protrusions and not myosin II contractility. Epidermal progenitor monolayer formation and epidermal spreading are delayed in Crash mice, which possess a dominant mutation in Celsr1, an orthologue of the core planar cell polarity (PCP) Drosophila protein Flamingo (also known as Stan). We observe a failure of ventral enclosure in Crash mutants suggesting that defective epidermal spreading might underlie some ventral wall birth defects. Twit Text FOAVip Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26989131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26989131 #FOAvip English Wikipedia <ref>{{Cite pmid|26989131}}</ref> Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body #MMPMID26989131 Panousopoulou E; Hobbs C; Mason I; Green JBA; Formstone CJ J Cell Sci 2016[May]; 129 (9): 1915-27 PMID26989131show ga Epiboly is a morphogenetic process that is employed in the surface ectoderm of anamniotes during gastrulation to cover the entire embryo. We propose here that mammals also utilise this process to expand the epidermis and enclose the body cavity and spinal cord with a protective surface covering. Our data supports a model whereby epidermal spreading is driven by the primary establishment of the epidermal basal progenitor monolayer through radial cell intercalation of a multi-layered epithelium towards the basal lamina. By using a suspension organotypic culture strategy, we find that this process is fibronectin-dependent and autonomous to the skin. The radial cell rearrangements that drive epidermal spreading also require ROCK activity but are driven by cell protrusions and not myosin II contractility. Epidermal progenitor monolayer formation and epidermal spreading are delayed in Crash mice, which possess a dominant mutation in Celsr1, an orthologue of the core planar cell polarity (PCP) Drosophila protein Flamingo (also known as Stan). We observe a failure of ventral enclosure in Crash mutants suggesting that defective epidermal spreading might underlie some ventral wall birth defects. �Epiboly generates the epidermal basal monolayer and spreads the nascen(epmc).pdf DeepDyve Pubget Overpricing