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10.3892/or.2016.4822 http://scihub22266oqcxt.onion/10.3892/or.2016.4822 C4899013!4899013!27220595     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27220595.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Rep 2016 ; 36 (1): 108-16 Nephropedia Template TP {{tp|p=27220595|t=2016. STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer |pdf=|usr=}}{{27220595}} gab.com Text STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer JO: Oncol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27220595 #FOAvip Hypoxia plays a key role in tumour initiation and metastasis; one of the mechanisms is to induce epithelial-mesenchymal transition (EMT). Signal transducer and activator of transcription 3 (STAT3) is involved in EMT by regulating the transcriptional regulators of E-cadherin, the biomarker of EMT. Until now, however, few studies have focused on the effects of STAT3 in hypoxia-induced EMT in tumour cells. The goal of this study was to investigate the roles of STAT3 in hypoxia-induced EMT in oesophageal squamous cell carcinoma (ESCC). The ESCC cells, TE-1 and EC-1, were incubated in normoxia, or in CoCl2, which was used to mimic hypoxia. With CoCl2, the ESCC cells showed increased migration and invasion abilities, accompanied with upregulation of HIF-1?, STAT3, and vimentin, and downregulation of E-cadherin. Knockdown of STAT3 inhibited EMT of ESCC cells and downregulated HIF-1? in vitro and in vivo. In ChIP assays, STAT3 bound to the promoter of HIF-1?, suggesting that STAT3 regulates transcription of HIF-1?. In conclusion, hypoxia induces EMT of ESCC, and STAT3 regulates this process by promoting HIF-1? expression. Twit Text FOAVip STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer ????Oncol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27220595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27220595 #FOAvip English Wikipedia <ref>{{Cite pmid|27220595}}</ref> STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer #MMPMID27220595 CUI Y; LI YY; LI J; ZHANG HY; WANG F; BAI X; LI SS Oncol Rep 2016[Jul]; 36 (1): 108-16 PMID27220595show ga Hypoxia plays a key role in tumour initiation and metastasis; one of the mechanisms is to induce epithelial-mesenchymal transition (EMT). Signal transducer and activator of transcription 3 (STAT3) is involved in EMT by regulating the transcriptional regulators of E-cadherin, the biomarker of EMT. Until now, however, few studies have focused on the effects of STAT3 in hypoxia-induced EMT in tumour cells. The goal of this study was to investigate the roles of STAT3 in hypoxia-induced EMT in oesophageal squamous cell carcinoma (ESCC). The ESCC cells, TE-1 and EC-1, were incubated in normoxia, or in CoCl2, which was used to mimic hypoxia. With CoCl2, the ESCC cells showed increased migration and invasion abilities, accompanied with upregulation of HIF-1?, STAT3, and vimentin, and downregulation of E-cadherin. Knockdown of STAT3 inhibited EMT of ESCC cells and downregulated HIF-1? in vitro and in vivo. In ChIP assays, STAT3 bound to the promoter of HIF-1?, suggesting that STAT3 regulates transcription of HIF-1?. In conclusion, hypoxia induces EMT of ESCC, and STAT3 regulates this process by promoting HIF-1? expression. äSTAT3 regulates hypoxia-induced epithelial mesenchymal transition in o(epmc).pdf DeepDyve Pubget Overpricing