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10.1016/j.canlet.2015.12.003 http://scihub22266oqcxt.onion/10.1016/j.canlet.2015.12.003 C4902790!4902790!26688098     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26688098&cmd=llinks): Failed to open stream: HTTP request failed! 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Recapitulation of complex transport and action of drugs at tumor microenvironment using tumor-microenvironment-on-chip |pdf=|usr=}}{{26688098}} gab.com Text Recapitulation of complex transport and action of drugs at tumor microenvironment using tumor-microenvironment-on-chip JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26688098 #FOAvip Targeted delivery aims to selectively distribute drugs to targeted tumor tissue but not to healthy tissue. This can address many of clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicines. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery was discussed, and the current status and challenges for developing in vitro transport model systems was reviewed. Twit Text FOAVip Recapitulation of complex transport and action of drugs at tumor microenvironment using tumor-microenvironment-on-chip ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26688098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26688098 #FOAvip English Wikipedia <ref>{{Cite pmid|26688098}}</ref> Recapitulation of complex transport and action of drugs at tumor microenvironment using tumor-microenvironment-on-chip #MMPMID26688098 Han B; Qu C; Park K; Konieczny SF; Korc M Cancer Lett 2016[Sep]; 380 (1): 319-29 PMID26688098show ga Targeted delivery aims to selectively distribute drugs to targeted tumor tissue but not to healthy tissue. This can address many of clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicines. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery was discussed, and the current status and challenges for developing in vitro transport model systems was reviewed. äRecapitulation of complex transport and action of drugs at tumor micro(epmc).pdf DeepDyve Pubget Overpricing