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10.1158/1541-7786.MCR-16-0050 http://scihub22266oqcxt.onion/10.1158/1541-7786.MCR-16-0050 C4912396!4912396!27084311     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27084311&cmd=llinks): Failed to open stream: HTTP request failed! 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Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-mesenchymal Transition: Effects on Anoikis |pdf=|usr=}}{{27084311}} gab.com Text Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-mesenchymal Transition: Effects on Anoikis JO: Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27084311 #FOAvip Resistance to anoikis is a pre-requisite for tumor metastasis. The epithelial-to-mesenchymal transition (EMT) allows tumor cells to evade anoikis. The wound healing regulatory transcription factor Grainyhead-like 2 (GRHL2) suppresses/reverses EMT, accompanied by suppression of the cancer stem cell (CSC) phenotype and by re-sensitization to anoikis. Here, the effects of GRHL2 upon intracellular metabolism in the context of reversion of the EMT/CSC phenotype, with a view toward understanding how these effects promote anoikis sensitivity were investigated. EMT enhanced mitochondrial oxidative metabolism. While this was accompanied by higher accumulation of superoxide, the overall level of Reactive Oxygen Species (ROS) declined, due to decreased hydrogen peroxide. Glutamate Dehydrogenase 1 (GLUD1) expression increased in EMT, and this increase, via the product ?-ketoglutarate (?-KG), was important for suppressing hydrogen peroxide and protecting against anoikis. GRHL2 suppressed GLUD1 gene expression, decreased ?-KG, increased ROS and sensitized cells to anoikis.Implications: These results demonstrate a mechanistic role for GRHL2 in promoting anoikis through metabolic alterations. Twit Text FOAVip Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-mesenchymal Transition: Effects on Anoikis ????Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27084311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27084311 #FOAvip English Wikipedia <ref>{{Cite pmid|27084311}}</ref> Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-mesenchymal Transition: Effects on Anoikis #MMPMID27084311 Farris JC; Pifer PM; Zheng L; Gottlieb E; Denvir J; Frisch SM Mol Cancer Res 2016[Jun]; 14 (6): 528-38 PMID27084311show ga Resistance to anoikis is a pre-requisite for tumor metastasis. The epithelial-to-mesenchymal transition (EMT) allows tumor cells to evade anoikis. The wound healing regulatory transcription factor Grainyhead-like 2 (GRHL2) suppresses/reverses EMT, accompanied by suppression of the cancer stem cell (CSC) phenotype and by re-sensitization to anoikis. Here, the effects of GRHL2 upon intracellular metabolism in the context of reversion of the EMT/CSC phenotype, with a view toward understanding how these effects promote anoikis sensitivity were investigated. EMT enhanced mitochondrial oxidative metabolism. While this was accompanied by higher accumulation of superoxide, the overall level of Reactive Oxygen Species (ROS) declined, due to decreased hydrogen peroxide. Glutamate Dehydrogenase 1 (GLUD1) expression increased in EMT, and this increase, via the product ?-ketoglutarate (?-KG), was important for suppressing hydrogen peroxide and protecting against anoikis. GRHL2 suppressed GLUD1 gene expression, decreased ?-KG, increased ROS and sensitized cells to anoikis.Implications: These results demonstrate a mechanistic role for GRHL2 in promoting anoikis through metabolic alterations. äGrainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncoge(epmc).pdf DeepDyve Pubget Overpricing