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10.1016/j.rmcr.2016.04.004

http://scihub22266oqcxt.onion/10.1016/j.rmcr.2016.04.004
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suck abstract from ncbi


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pmid27330950      Respir+Med+Case+Rep 2016 ; 18 (ä): 48-50
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  • Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy A case report #MMPMID27330950
  • Calzas Rodríguez J; Carmen Juarez Morales Md; Casero MAR
  • Respir Med Case Rep 2016[]; 18 (ä): 48-50 PMID27330950show ga
  • With cisplatin-based chemotherapy, most patients with ovarian dysgerminoma will survive long-term. Bleomycin is an important part of ovarian germ cell tumors (OGCT) treatment, and its dose-limiting toxicity is the development of pulmonary toxicity and it is increased in patients older than 40 years. We report the case of an elderly patient with an unresectable ovarian dysgerminoma who received neoadjuvant chemotherapy and who developed fatal bleomycin pulmonary toxicity (BPT) after surgery. A monitoring of pulmonary function is not routinely recommended for detecting BPT, although together with carefully assessment for symptoms or signs suggestive of pulmonary toxicity is the best way to reduce the risk of BPT. The frequency of pulmonary events in older patients makes us to think about the possibility of either reduce the dose of bleomycin or removing it from the BEP in ovarian GCT.
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