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10.1038/ncomms11904 http://scihub22266oqcxt.onion/10.1038/ncomms11904 C4915028!4915028!27312851     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27312851.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27312851|t=2016. Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1? for Th17 suppression |pdf=|usr=}}{{27312851}} gab.com Text Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1 for Th17 suppression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27312851 #FOAvip Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17) and prevents Th17-mediated pathology in a mouse model of autoimmunity. We demonstrate that DAPK specifically downregulates hypoxia-inducible factor 1? (HIF-1?). In contrast to the predominant nuclear localization of HIF-1? in many cell types, HIF-1? is located in both the cytoplasm and nucleus in T cells, allowing for a cytosolic DAPK?HIF-1? interaction. DAPK also binds prolyl hydroxylase domain protein 2 (PHD2) and increases HIF-1?-PHD2 association. DAPK thereby promotes the proline hydroxylation and proteasome degradation of HIF-1?. Consequently, DAPK deficiency leads to excess HIF-1? accumulation, enhanced IL-17 expression and exacerbated experimental autoimmune encephalomyelitis. Additional knockout of HIF-1? restores the normal differentiation of Dapk?/? Th17 cells and prevents experimental autoimmune encephalomyelitis development. Our results reveal a mechanism involving DAPK-mediated degradation of cytoplasmic HIF-1?, and suggest that raising DAPK levels could be used for treatment of Th17-associated inflammatory diseases. Twit Text FOAVip Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1 for Th17 suppression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27312851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27312851 #FOAvip English Wikipedia <ref>{{Cite pmid|27312851}}</ref> Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1? for Th17 suppression #MMPMID27312851 Chou TF; Chuang YT; Hsieh WC; Chang PY; Liu HY; Mo ST; Hsu TS; Miaw SC; Chen RH; Kimchi A; Lai MZ Nat Commun 2016[]; 7 (ä): ä PMID27312851show ga Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17) and prevents Th17-mediated pathology in a mouse model of autoimmunity. We demonstrate that DAPK specifically downregulates hypoxia-inducible factor 1? (HIF-1?). In contrast to the predominant nuclear localization of HIF-1? in many cell types, HIF-1? is located in both the cytoplasm and nucleus in T cells, allowing for a cytosolic DAPK?HIF-1? interaction. DAPK also binds prolyl hydroxylase domain protein 2 (PHD2) and increases HIF-1?-PHD2 association. DAPK thereby promotes the proline hydroxylation and proteasome degradation of HIF-1?. Consequently, DAPK deficiency leads to excess HIF-1? accumulation, enhanced IL-17 expression and exacerbated experimental autoimmune encephalomyelitis. Additional knockout of HIF-1? restores the normal differentiation of Dapk?/? Th17 cells and prevents experimental autoimmune encephalomyelitis development. Our results reveal a mechanism involving DAPK-mediated degradation of cytoplasmic HIF-1?, and suggest that raising DAPK levels could be used for treatment of Th17-associated inflammatory diseases. äTumour suppressor death-associated protein kinase targets cytoplasmic (epmc).pdf DeepDyve Pubget Overpricing