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10.1111/j.1750-2659.2011.00235.x http://scihub22266oqcxt.onion/10.1111/j.1750-2659.2011.00235.x C4942046!4942046!21668689     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21668689&cmd=llinks): Failed to open stream: HTTP request failed! 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Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung |pdf=|usr=}}{{21668689}} gab.com Text Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung JO: Influenza Other Respir Viruses http://www.kidney.de/pget.php?&tw=1&pmid=21668689 #FOAvip Please cite this paper as: Wong et al. (2011) Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung. Influenza and Other Respiratory Viruses 5(5), 343?350.Background? Lung inflammation is a critical determinant of influenza infection outcomes but is seldom evaluated in animal studies of oseltamivir (OS), which have focused on viral titre and survival.Objectives? To study the effects of pre? and post?infection dosing with OS on viral replication and inflammation in a mouse model of non?lethal influenza infection.Methods? BALB/c mice were infected with a laboratory?adapted H3N1 strain of influenza. In pre?dosing studies, OS was gavaged twice daily (1 and 10?mg/kg/day) from 4?hours prior to infection and continuing for 5?days (d) post?infection (p.i). In the second post?infection dosing study, dosing at 10?mg/kg/day began at 24?48?hours p.i. Mice were dissected at d3, d5 and d7?p.i. (pre?dosing study) and d5?p.i. (post?dosing study). Lung viral titres were determined by plaque assay. Bronchoalveolar lavage fluid (BALF) was collected and used for the quantitation of inflammatory cells and mediators.Results? Pre?infection dosing of OS reduced total cells, neutrophils and macrophages in BALF. With pre? or post?infection dosing, the pro?inflammatory mediators TNF??, IL?1?, IL?6 and granulocyte?macrophage colony?stimulating factor, the neutrophil chemokines keratinocyte?derived chemokine and MIP?1? and the macrophage chemokine MCP?1 were reduced in BALF. Pre?dosing with 1?mg/kg OS did not reduce viral titres, while 10?mg/kg slightly reduced viral titres at d3 and d5?p.i.Conclusions? Oseltamivir reduced the inflammatory response to influenza when given pre? or post?infection. This anti?inflammatory effect may contribute to the clinical benefit of OS. Twit Text FOAVip Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung ????Influenza Other Respir Viruses http://www.kidney.de/pget.php?&tw=1&pmid=21668689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21668689 #FOAvip English Wikipedia <ref>{{Cite pmid|21668689}}</ref> Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung #MMPMID21668689 Wong ZX; Jones JE; Anderson GP; Gualano RC Influenza Other Respir Viruses 2011[Sep]; 5 (5): 343-50 PMID21668689show ga Please cite this paper as: Wong et al. (2011) Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung. Influenza and Other Respiratory Viruses 5(5), 343?350.Background? Lung inflammation is a critical determinant of influenza infection outcomes but is seldom evaluated in animal studies of oseltamivir (OS), which have focused on viral titre and survival.Objectives? To study the effects of pre? and post?infection dosing with OS on viral replication and inflammation in a mouse model of non?lethal influenza infection.Methods? BALB/c mice were infected with a laboratory?adapted H3N1 strain of influenza. In pre?dosing studies, OS was gavaged twice daily (1 and 10?mg/kg/day) from 4?hours prior to infection and continuing for 5?days (d) post?infection (p.i). In the second post?infection dosing study, dosing at 10?mg/kg/day began at 24?48?hours p.i. Mice were dissected at d3, d5 and d7?p.i. (pre?dosing study) and d5?p.i. (post?dosing study). Lung viral titres were determined by plaque assay. Bronchoalveolar lavage fluid (BALF) was collected and used for the quantitation of inflammatory cells and mediators.Results? Pre?infection dosing of OS reduced total cells, neutrophils and macrophages in BALF. With pre? or post?infection dosing, the pro?inflammatory mediators TNF??, IL?1?, IL?6 and granulocyte?macrophage colony?stimulating factor, the neutrophil chemokines keratinocyte?derived chemokine and MIP?1? and the macrophage chemokine MCP?1 were reduced in BALF. Pre?dosing with 1?mg/kg OS did not reduce viral titres, while 10?mg/kg slightly reduced viral titres at d3 and d5?p.i.Conclusions? Oseltamivir reduced the inflammatory response to influenza when given pre? or post?infection. This anti?inflammatory effect may contribute to the clinical benefit of OS. äOseltamivir treatment of mice before or after mild influenza infection(epmc).pdf DeepDyve Pubget Overpricing