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10.1016/j.tins.2016.05.002 http://scihub22266oqcxt.onion/10.1016/j.tins.2016.05.002 C4967375!4967375!27325209     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27325209.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Neurosci 2016 ; 39 (8): 552-66 Nephropedia Template TP {{tp|p=27325209|t=2016. Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer s disease?|pdf=|usr=}}{{27325209}} gab.com Text Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer s disease JO: Trends Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27325209 #FOAvip Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD. Moreover, insufficient sleep facilitates accumulation of amyloid-? (A?), potentially triggering earlier cognitive decline and conversion to AD. Building on such findings, this review has four goals, evaluating: (i) associations and plausible mechanisms linking NREM sleep disruption, A?, and AD, (ii) a role for NREM sleep disruption as a novel factor linking cortical A? to impaired hippocampus-dependent memory consolidation, (iii) the potential diagnostic utility of NREM sleep disruption as a new biomarker of AD, and (iv) the possibility of sleep as a new treatment target in aging, affording preventative and therapeutic benefits. Twit Text FOAVip Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer s disease ????Trends Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27325209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27325209 #FOAvip English Wikipedia <ref>{{Cite pmid|27325209}}</ref> Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer s disease? #MMPMID27325209 Mander BA; Winer JR; Jagust WJ; Walker MP Trends Neurosci 2016[Aug]; 39 (8): 552-66 PMID27325209show ga Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD. Moreover, insufficient sleep facilitates accumulation of amyloid-? (A?), potentially triggering earlier cognitive decline and conversion to AD. Building on such findings, this review has four goals, evaluating: (i) associations and plausible mechanisms linking NREM sleep disruption, A?, and AD, (ii) a role for NREM sleep disruption as a novel factor linking cortical A? to impaired hippocampus-dependent memory consolidation, (iii) the potential diagnostic utility of NREM sleep disruption as a new biomarker of AD, and (iv) the possibility of sleep as a new treatment target in aging, affording preventative and therapeutic benefits. äSleep: A novel mechanistic pathway, biomarker, and treatment target in(epmc).pdf DeepDyve Pubget Overpricing