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10.1038/bjc.2016.160 http://scihub22266oqcxt.onion/10.1038/bjc.2016.160 C4984476!4984476!27253174     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27253174&cmd=llinks): Failed to open stream: HTTP request failed! 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Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial |pdf=|usr=}}{{27253174}} gab.com Text Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27253174 #FOAvip Background:: Ghrelin, a 28-amino acid peptide predominantly produced by the stomach, exerts powerful renal protective effects by increasing levels of insulin-like growth factor-1 (IGF-1). The aim of this study was to evaluate the effects of ghrelin on the incidence of renal dysfunction in patients receiving cisplatin-based chemotherapy. Methods:: Forty patients with oesophageal cancer receiving cisplatin-based chemotherapy were assigned to either the ghrelin group (n=20), which received ghrelin (0.5??g?kg?1?h?1) for 5 days, or a placebo group (n=20). The primary endpoint was serum creatinine. Secondary endpoints were serum cystatin C, chemotherapy-related adverse events, changes in serum ghrelin-related hormone levels, correlation between markers of renal injury and hormone concentrations, and effects on the second cycle of chemotherapy. Results:: Blood acyl ghrelin, total ghrelin, and IGF-1 concentrations on day 4 were significantly higher in the ghrelin group. The renal dysfunction, serum creatinine and cystatin C levels, dose reduction, and delay in the initiation of the second cycle of chemotherapy were lower in the ghrelin group than in the control group. Serum creatinine levels were significantly correlated with serum IGF-1 levels. Conclusion:: Continuous synthetic ghrelin administration during cisplatin-based chemotherapy attenuated renal dysfunction and harmful effects on subsequent chemotherapy, possibly by increasing IGF-1 levels. Twit Text FOAVip Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27253174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27253174 #FOAvip English Wikipedia <ref>{{Cite pmid|27253174}}</ref> Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial #MMPMID27253174 Yanagimoto Y; Takiguchi S; Miyazaki Y; Makino T; Takahashi T; Kurokawa Y; Yamasaki M; Miyata H; Nakajima K; Hosoda H; Kangawa K; Mori M; Doki Y Br J Cancer 2016[Jun]; 114 (12): 1318-25 PMID27253174show ga Background:: Ghrelin, a 28-amino acid peptide predominantly produced by the stomach, exerts powerful renal protective effects by increasing levels of insulin-like growth factor-1 (IGF-1). The aim of this study was to evaluate the effects of ghrelin on the incidence of renal dysfunction in patients receiving cisplatin-based chemotherapy. Methods:: Forty patients with oesophageal cancer receiving cisplatin-based chemotherapy were assigned to either the ghrelin group (n=20), which received ghrelin (0.5??g?kg?1?h?1) for 5 days, or a placebo group (n=20). The primary endpoint was serum creatinine. Secondary endpoints were serum cystatin C, chemotherapy-related adverse events, changes in serum ghrelin-related hormone levels, correlation between markers of renal injury and hormone concentrations, and effects on the second cycle of chemotherapy. Results:: Blood acyl ghrelin, total ghrelin, and IGF-1 concentrations on day 4 were significantly higher in the ghrelin group. The renal dysfunction, serum creatinine and cystatin C levels, dose reduction, and delay in the initiation of the second cycle of chemotherapy were lower in the ghrelin group than in the control group. Serum creatinine levels were significantly correlated with serum IGF-1 levels. Conclusion:: Continuous synthetic ghrelin administration during cisplatin-based chemotherapy attenuated renal dysfunction and harmful effects on subsequent chemotherapy, possibly by increasing IGF-1 levels. äImprovement of cisplatin-related renal dysfunction by synthetic ghreli(epmc).pdf DeepDyve Pubget Overpricing