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10.1097/OLQ.0000000000000500 http://scihub22266oqcxt.onion/10.1097/OLQ.0000000000000500 C4985051!4985051!27513384     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27513384&cmd=llinks): Failed to open stream: HTTP request failed! 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Higher HPV16 and HPV18 Penile Viral Loads are associated with Decreased HPV Clearance in Uncircumcised Kenyan Men |pdf=|usr=}}{{27513384}} gab.com Text Higher HPV16 and HPV18 Penile Viral Loads are associated with Decreased HPV Clearance in Uncircumcised Kenyan Men JO: Sex Transm Dis http://www.kidney.de/pget.php?&tw=1&pmid=27513384 #FOAvip Background: Whether higher penile human papillomavirus(HPV) viral load is associated with a lower rate of HPV clearance remains unknown. Objectives: We examined the association between penile HPV16 and HPV18 viral load and subsequent HPV clearance in uncircumcised Kenyan men. Study Design: Participants were HIV-seronegative, sexually active, 18?24 year old men randomized to the control arm of a male circumcision trial in Kisumu, Kenya. Men provided exfoliated penile cells from two anatomical sites (glans/coronal sulcus and shaft) every 6 months for 2 years. GP5+/6+ polymerase chain reaction(PCR) was used to identify 44 HPV-DNA types. HPV viral load testing was conducted using a LightCyler real-time PCR assay; viral load was classified as high(> 250 copies/scrape) or low(?250 copies/scrape), for non-quantifiable values. The Kaplan-Meier method and Cox regression modelling were used to examine the association between HPV viral load and HPV clearance. Results: A total of 1097 men, with 291 HPV16 and 131 HPV18 cumulative infections over 24 months were analyzed. HPV clearance at 6 months after first HPV detection was lower for high versus low viral load HPV16 infections in the glans [adjusted hazard ratio (aHR) = 0.65(95% confidence interval, 0.46-0.92)] and shaft (aHR=0.44(0.16-0.90), and HPV18 infections in the glans [aHR=0.05(0.01-0.17)]. Discussion: High versus low HPV viral load was associated with reduced HPV clearance for HPV16 infections in the glans and shaft, and for HPV18 infections in the glans, among young uncircumcised men. Reduced clearance of high viral load HPV16 and HPV18 infections in men may increase HPV transmission to their female partners as well as enhance the development of penile lesions in comparison to men with low viral load HPV infections. Twit Text FOAVip Higher HPV16 and HPV18 Penile Viral Loads are associated with Decreased HPV Clearance in Uncircumcised Kenyan Men ????Sex Transm Dis http://www.kidney.de/pget.php?&tw=1&pmid=27513384 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27513384 #FOAvip English Wikipedia <ref>{{Cite pmid|27513384}}</ref> Higher HPV16 and HPV18 Penile Viral Loads are associated with Decreased HPV Clearance in Uncircumcised Kenyan Men #MMPMID27513384 Senkomago V; Backes DM; Hudgens MG; Poole C; Meshnick SR; Agot K; Moses S; Snijders PJ; Meijer CJ; Hesselink AT; Schlecht NF; Bailey RC; Smith JS Sex Transm Dis 2016[Sep]; 43 (9): 572-8 PMID27513384show ga Background: Whether higher penile human papillomavirus(HPV) viral load is associated with a lower rate of HPV clearance remains unknown. Objectives: We examined the association between penile HPV16 and HPV18 viral load and subsequent HPV clearance in uncircumcised Kenyan men. Study Design: Participants were HIV-seronegative, sexually active, 18?24 year old men randomized to the control arm of a male circumcision trial in Kisumu, Kenya. Men provided exfoliated penile cells from two anatomical sites (glans/coronal sulcus and shaft) every 6 months for 2 years. GP5+/6+ polymerase chain reaction(PCR) was used to identify 44 HPV-DNA types. HPV viral load testing was conducted using a LightCyler real-time PCR assay; viral load was classified as high(> 250 copies/scrape) or low(?250 copies/scrape), for non-quantifiable values. The Kaplan-Meier method and Cox regression modelling were used to examine the association between HPV viral load and HPV clearance. Results: A total of 1097 men, with 291 HPV16 and 131 HPV18 cumulative infections over 24 months were analyzed. HPV clearance at 6 months after first HPV detection was lower for high versus low viral load HPV16 infections in the glans [adjusted hazard ratio (aHR) = 0.65(95% confidence interval, 0.46-0.92)] and shaft (aHR=0.44(0.16-0.90), and HPV18 infections in the glans [aHR=0.05(0.01-0.17)]. Discussion: High versus low HPV viral load was associated with reduced HPV clearance for HPV16 infections in the glans and shaft, and for HPV18 infections in the glans, among young uncircumcised men. Reduced clearance of high viral load HPV16 and HPV18 infections in men may increase HPV transmission to their female partners as well as enhance the development of penile lesions in comparison to men with low viral load HPV infections. äHigher HPV16 and HPV18 Penile Viral Loads are associated with Decrease(epmc).pdf DeepDyve Pubget Overpricing