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10.18632/oncotarget.8344 http://scihub22266oqcxt.onion/10.18632/oncotarget.8344 C4991385!4991385!27027355     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27027355&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27027355.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (15): 19312-26 Nephropedia Template TP {{tp|p=27027355|t=2016. 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation |pdf=|usr=}}{{27027355}} gab.com Text 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27027355 #FOAvip While it is well established that treatment of cancer patients with 5-Fluorouracil (5-FU) can result in immune suppression, the exact function of 5-FU in the modulation of immune cells has not been fully established. We found that low dose 5-FU selectively suppresses TH17 and TH1 cell differentiation without apparent effect on Treg, TH2, and significantly suppresses thymidylate synthase (TS) expression in TH17 and TH1 cells but has a lesser effect in tumor cells and macrophages. Interestingly, the basal expression of TS varies significantly between T helper phenotypes and knockdown of TS significantly impairs TH17 and TH1 cell differentiation without affecting the differentiation of either Treg or TH2 cells. Finally, low dose 5-FU is effective in ameliorating colitis development by suppressing TH17 and TH1 cell development in a T cell transfer colitis model. Taken together, the results highlight the importance of the anti-inflammatory functions of low dose 5-FU by selectively suppressing TH17 and TH1 immune responses. Twit Text FOAVip 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27027355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27027355 #FOAvip English Wikipedia <ref>{{Cite pmid|27027355}}</ref> 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation #MMPMID27027355 Wang J; Peng L; Zhang R; Zheng Z; Chen C; Cheung KL; Cui M; Bian G; Xu F; Chiang D; Hu Y; Chen Y; Lu G; Yang J; Zhang H; Yang J; Zhu H; Chen Sh; Liu K; Zhou MM; Sikora AG; Li L; Jiang B; Xiong H Oncotarget 2016[Apr]; 7 (15): 19312-26 PMID27027355show ga While it is well established that treatment of cancer patients with 5-Fluorouracil (5-FU) can result in immune suppression, the exact function of 5-FU in the modulation of immune cells has not been fully established. We found that low dose 5-FU selectively suppresses TH17 and TH1 cell differentiation without apparent effect on Treg, TH2, and significantly suppresses thymidylate synthase (TS) expression in TH17 and TH1 cells but has a lesser effect in tumor cells and macrophages. Interestingly, the basal expression of TS varies significantly between T helper phenotypes and knockdown of TS significantly impairs TH17 and TH1 cell differentiation without affecting the differentiation of either Treg or TH2 cells. Finally, low dose 5-FU is effective in ameliorating colitis development by suppressing TH17 and TH1 cell development in a T cell transfer colitis model. Taken together, the results highlight the importance of the anti-inflammatory functions of low dose 5-FU by selectively suppressing TH17 and TH1 immune responses. ä5-Fluorouracil targets thymidylate synthase in the selective suppressi(epmc).pdf DeepDyve Pubget Overpricing