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10.1093/infdis/jiw201 http://scihub22266oqcxt.onion/10.1093/infdis/jiw201 C4996146!4996146!27190184     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27190184&cmd=llinks): Failed to open stream: HTTP request failed! 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Streptococcus oralis and Candida albicans Synergistically Activate ?-Calpain to Degrade E-cadherin From Oral Epithelial Junctions |pdf=|usr=}}{{27190184}} gab.com Text Streptococcus oralis and Candida albicans Synergistically Activate -Calpain to Degrade E-cadherin From Oral Epithelial Junctions JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=27190184 #FOAvip Streptococcus oralis forms robust mucosal biofilms with Candida albicans that have increased pathogenic potential. In this study, using oral epithelial cultures, organotypic oral mucosal constructs, and a mouse model of oral infection, we demonstrated that S. oralis augmented C. albicans invasion through epithelial junctions. C. albicans and S. oralis decreased epithelial E-cadherin levels by synergistically increasing �-calpain, a proteolytic enzyme that targets E-cadherin. In the mouse coinfection model this was accompanied by increased fungal kidney dissemination. Coinfection with a secreted aspartyl protease (sap) mutant sap2456 and S. oralis increased ?-calpain and triggered mucosal invasion and systemic dissemination, suggesting that fungal protease activity is not required for invasion during coinfection. We conclude that C. albicans and S. oralis synergize to activate host enzymes that cleave epithelial junction proteins and increase fungal invasion. Twit Text FOAVip Streptococcus oralis and Candida albicans Synergistically Activate -Calpain to Degrade E-cadherin From Oral Epithelial Junctions ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=27190184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27190184 #FOAvip English Wikipedia <ref>{{Cite pmid|27190184}}</ref> Streptococcus oralis and Candida albicans Synergistically Activate ?-Calpain to Degrade E-cadherin From Oral Epithelial Junctions #MMPMID27190184 Xu H; Sobue T; Bertolini M; Thompson A; Dongari-Bagtzoglou A J Infect Dis 2016[Sep]; 214 (6): 925-34 PMID27190184show ga Streptococcus oralis forms robust mucosal biofilms with Candida albicans that have increased pathogenic potential. In this study, using oral epithelial cultures, organotypic oral mucosal constructs, and a mouse model of oral infection, we demonstrated that S. oralis augmented C. albicans invasion through epithelial junctions. C. albicans and S. oralis decreased epithelial E-cadherin levels by synergistically increasing �-calpain, a proteolytic enzyme that targets E-cadherin. In the mouse coinfection model this was accompanied by increased fungal kidney dissemination. Coinfection with a secreted aspartyl protease (sap) mutant sap2456 and S. oralis increased ?-calpain and triggered mucosal invasion and systemic dissemination, suggesting that fungal protease activity is not required for invasion during coinfection. We conclude that C. albicans and S. oralis synergize to activate host enzymes that cleave epithelial junction proteins and increase fungal invasion. �Streptococcus oralis and Candida albicans Synergistically Activate ?-C(epmc).pdf DeepDyve Pubget Overpricing