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10.1038/srep32000 http://scihub22266oqcxt.onion/10.1038/srep32000 C4999957!4999957!27561946     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27561946&cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-? production by mononuclear phagocytes |pdf=|usr=}}{{27561946}} gab.com Text Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF- production by mononuclear phagocytes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27561946 #FOAvip Infection by the dengue virus (DENV) threatens global public health due to its high prevalence and the lack of effective treatments. Host factors may contribute to the pathogenesis of DENV; herein, we investigated the role of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is activated by DENV in mononuclear phagocytes. DENV infection selectively activates Nrf2 following nuclear translocation. Following endoplasmic reticular (ER) stress, protein kinase R-like ER kinase (PERK) facilitated Nrf2-mediated transcriptional activation of C-type lectin domain family 5, member A (CLEC5A) to increase CLEC5A expression. Signaling downstream of the Nrf2-CLEC5A interaction enhances Toll-like receptor 3 (TLR3)-independent tumor necrosis factor (TNF)-? production following DENV infection. Forced expression of the NS2B3 viral protein induces Nrf2 nuclear translocation/activation and CLEC5A expression which increases DENV-induced TNF-? production. Animal studies confirmed Nrf2-induced CLEC5A and TNF-? in brains of DENV-infected mice. These results demonstrate that DENV infection causes Nrf2-regulated TNF-? production by increasing levels of CLEC5A. Twit Text FOAVip Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF- production by mononuclear phagocytes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27561946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27561946 #FOAvip English Wikipedia <ref>{{Cite pmid|27561946}}</ref> Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-? production by mononuclear phagocytes #MMPMID27561946 Cheng YL; Lin YS; Chen CL; Tsai TT; Tsai CC; Wu YW; Ou YD; Chu YY; Wang JM; Yu CY; Lin CF Sci Rep 2016[]; 6 (ä): ä PMID27561946show ga Infection by the dengue virus (DENV) threatens global public health due to its high prevalence and the lack of effective treatments. Host factors may contribute to the pathogenesis of DENV; herein, we investigated the role of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is activated by DENV in mononuclear phagocytes. DENV infection selectively activates Nrf2 following nuclear translocation. Following endoplasmic reticular (ER) stress, protein kinase R-like ER kinase (PERK) facilitated Nrf2-mediated transcriptional activation of C-type lectin domain family 5, member A (CLEC5A) to increase CLEC5A expression. Signaling downstream of the Nrf2-CLEC5A interaction enhances Toll-like receptor 3 (TLR3)-independent tumor necrosis factor (TNF)-? production following DENV infection. Forced expression of the NS2B3 viral protein induces Nrf2 nuclear translocation/activation and CLEC5A expression which increases DENV-induced TNF-? production. Animal studies confirmed Nrf2-induced CLEC5A and TNF-? in brains of DENV-infected mice. These results demonstrate that DENV infection causes Nrf2-regulated TNF-? production by increasing levels of CLEC5A. äActivation of Nrf2 by the dengue virus causes an increase in CLEC5A, w(epmc).pdf DeepDyve Pubget Overpricing