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10.1073/pnas.1606482113 http://scihub22266oqcxt.onion/10.1073/pnas.1606482113 C5018773!5018773!27559086     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27559086&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27559086.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (36): E5281-7 Nephropedia Template TP {{tp|p=27559086|t=2016. Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein |pdf=|usr=}}{{27559086}} gab.com Text Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27559086 #FOAvip Aggregation of proteins of known sequence is linked to a variety of neurodegenerative disorders. Familial mutations in the amyloid precursor protein (APP), from which the amyloid ? (A?) protein is excised, are associated with early onset of Alzheimer?s disease. The structures of APP-C99 dimers and the associated stability as well as the monomer?dimer equilibrium are critically influenced by membrane composition. Using a multiscale modeling approach, we have investigated the influence of varying lipid composition on the structure of homodimers of an APP-C99 congener peptide. Besides resolving contradicting experimental results, we demonstrate that membrane lipid composition dramatically influences the relative populations of competing homodimer structures in a way that is linked to the recognition and processing of APP-C99 by ?-secretase. Twit Text FOAVip Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27559086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27559086 #FOAvip English Wikipedia <ref>{{Cite pmid|27559086}}</ref> Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein #MMPMID27559086 Dominguez L; Foster L; Straub JE; Thirumalai D Proc Natl Acad Sci U S A 2016[Sep]; 113 (36): E5281-7 PMID27559086show ga Aggregation of proteins of known sequence is linked to a variety of neurodegenerative disorders. Familial mutations in the amyloid precursor protein (APP), from which the amyloid ? (A?) protein is excised, are associated with early onset of Alzheimer?s disease. The structures of APP-C99 dimers and the associated stability as well as the monomer?dimer equilibrium are critically influenced by membrane composition. Using a multiscale modeling approach, we have investigated the influence of varying lipid composition on the structure of homodimers of an APP-C99 congener peptide. Besides resolving contradicting experimental results, we demonstrate that membrane lipid composition dramatically influences the relative populations of competing homodimer structures in a way that is linked to the recognition and processing of APP-C99 by ?-secretase. äImpact of membrane lipid composition on the structure and stability of(epmc).pdf DeepDyve Pubget Overpricing