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10.1371/journal.ppat.1005884 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1005884 C5021349!5021349!27622514     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27622514&cmd=llinks): Failed to open stream: HTTP request failed! 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The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps |pdf=|usr=}}{{27622514}} gab.com Text The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=27622514 #FOAvip Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida growth and dissemination. Considering the resilience of Candida biofilms to host defenses, we examined the neutrophil response to C. albicans during biofilm growth. In contrast to planktonic C. albicans, biofilms triggered negligible release of NETs. Time lapse imaging confirmed the impairment in NET release and revealed neutrophils adhering to hyphae and migrating on the biofilm. NET inhibition depended on an intact extracellular biofilm matrix as physical or genetic disruption of this component resulted in NET release. Biofilm inhibition of NETosis could not be overcome by protein kinase C activation via phorbol myristate acetate (PMA) and was associated with suppression of neutrophil reactive oxygen species (ROS) production. The degree of impaired NET release correlated with resistance to neutrophil attack. The clinical relevance of the role for extracellular matrix in diminishing NET production was corroborated in vivo using a rat catheter model. The C. albicans pmr1?/?, defective in production of matrix mannan, appeared to elicit a greater abundance of NETs by scanning electron microscopy imaging, which correlated with a decreased fungal burden. Together, these findings show that C. albicans biofilms impair neutrophil response through an inhibitory pathway induced by the extracellular matrix. Twit Text FOAVip The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=27622514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27622514 #FOAvip English Wikipedia <ref>{{Cite pmid|27622514}}</ref> The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps #MMPMID27622514 Johnson CJ; Cabezas-Olcoz J; Kernien JF; Wang SX; Beebe DJ; Huttenlocher A; Ansari H; Nett JE PLoS Pathog 2016[Sep]; 12 (9): ä PMID27622514show ga Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida growth and dissemination. Considering the resilience of Candida biofilms to host defenses, we examined the neutrophil response to C. albicans during biofilm growth. In contrast to planktonic C. albicans, biofilms triggered negligible release of NETs. Time lapse imaging confirmed the impairment in NET release and revealed neutrophils adhering to hyphae and migrating on the biofilm. NET inhibition depended on an intact extracellular biofilm matrix as physical or genetic disruption of this component resulted in NET release. Biofilm inhibition of NETosis could not be overcome by protein kinase C activation via phorbol myristate acetate (PMA) and was associated with suppression of neutrophil reactive oxygen species (ROS) production. The degree of impaired NET release correlated with resistance to neutrophil attack. The clinical relevance of the role for extracellular matrix in diminishing NET production was corroborated in vivo using a rat catheter model. The C. albicans pmr1?/?, defective in production of matrix mannan, appeared to elicit a greater abundance of NETs by scanning electron microscopy imaging, which correlated with a decreased fungal burden. Together, these findings show that C. albicans biofilms impair neutrophil response through an inhibitory pathway induced by the extracellular matrix. äThe Extracellular Matrix of Candida albicans Biofilms Impairs Formatio(epmc).pdf DeepDyve Pubget Overpricing