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10.18632/oncotarget.8119 http://scihub22266oqcxt.onion/10.18632/oncotarget.8119 C5029685!5029685!26992223     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26992223.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (17): 24076-87 Nephropedia Template TP {{tp|p=26992223|t=2016. MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/?-catenin signaling in breast cancer |pdf=|usr=}}{{26992223}} gab.com Text MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/ -catenin signaling in breast cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26992223 #FOAvip Constitutive activation of the Wnt/?-catenin pathway promotes malignant proliferation and it is inversely correlated with the prognosis of patients with breast cancer. However, mutations in key regulators, such as APC, Axin and ?-catenin, contribute to aberrant activation of the Wnt/?-catenin signaling pathway in various cancers, but rarely found in breast cancer, suggesting that other mechanisms might be involved in the activation of Wnt/?-catenin signaling in breast cancer. In the present study, we found that miR-1229 expression was markedly upregulated in breast cancer and associated with poor survival. Overexpressing miR-1229 promoted while inhibiting miR-1229 reduced, proliferation of breast cancer cell proliferation in vitro and tumor growth in vivo. Furthermore, we found that overexpression of miR-1229 activated the Wnt/?-catenin signaling pathway in breast cancer by directly targeting the multiple important negative regulators of Wnt/?-catenin signaling, including adenomatous polyposis coli (APC), glycogen synthase kinase-3? (GSK-3?), and inhibitor of ?-catenin and T cell factor (ICAT). Taken together, our results suggest that miR-1229 plays an important role in promotion breast cancer progression and may represent a novel therapeutic target in breast cancer. Twit Text FOAVip MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/ -catenin signaling in breast cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26992223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26992223 #FOAvip English Wikipedia <ref>{{Cite pmid|26992223}}</ref> MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/?-catenin signaling in breast cancer #MMPMID26992223 Tan Z; Zheng H; Liu X; Zhang W; Zhu J; Wu G; Cao L; Song J; Wu S; Song L; Li J Oncotarget 2016[Apr]; 7 (17): 24076-87 PMID26992223show ga Constitutive activation of the Wnt/?-catenin pathway promotes malignant proliferation and it is inversely correlated with the prognosis of patients with breast cancer. However, mutations in key regulators, such as APC, Axin and ?-catenin, contribute to aberrant activation of the Wnt/?-catenin signaling pathway in various cancers, but rarely found in breast cancer, suggesting that other mechanisms might be involved in the activation of Wnt/?-catenin signaling in breast cancer. In the present study, we found that miR-1229 expression was markedly upregulated in breast cancer and associated with poor survival. Overexpressing miR-1229 promoted while inhibiting miR-1229 reduced, proliferation of breast cancer cell proliferation in vitro and tumor growth in vivo. Furthermore, we found that overexpression of miR-1229 activated the Wnt/?-catenin signaling pathway in breast cancer by directly targeting the multiple important negative regulators of Wnt/?-catenin signaling, including adenomatous polyposis coli (APC), glycogen synthase kinase-3? (GSK-3?), and inhibitor of ?-catenin and T cell factor (ICAT). Taken together, our results suggest that miR-1229 plays an important role in promotion breast cancer progression and may represent a novel therapeutic target in breast cancer. äMicroRNA-1229 overexpression promotes cell proliferation and tumorigen(epmc).pdf DeepDyve Pubget Overpricing