Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1611751113 http://scihub22266oqcxt.onion/10.1073/pnas.1611751113 C5035883!5035883!27601648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27601648&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27601648.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (38): 10625-30 Nephropedia Template TP {{tp|p=27601648|t=2016. Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production |pdf=|usr=}}{{27601648}} gab.com Text Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27601648 #FOAvip The identification of the Lon protease Cereblon as the thalidomide receptor has led to significant progress in our understanding of immunomodulatory drugs (IMiDs). IMiD binding alters the surface of Cereblon to facilitate the recruitment of proteins including Ikaros and CK1?. The recruitment of these proteins results in their ubiquitin-mediated proteosomal degradation. How Cereblon mediates the efficacy of these compounds in the treatment of inflammatory skin conditions remains unclear. Significantly, this study has identified Rabex-5 as a Cereblon-interacting protein that is affected by IMiD binding. Furthermore, knockdown studies in a human macrophage cell line reveals a function of Rabex-5 in regulating Toll-like receptor?induced type 1 IFN production. These findings may help explain the antiinflammatory properties of IMiDs. Twit Text FOAVip Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27601648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27601648 #FOAvip English Wikipedia <ref>{{Cite pmid|27601648}}</ref> Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production #MMPMID27601648 Millrine D; Tei M; Gemechu Y; Kishimoto T Proc Natl Acad Sci U S A 2016[Sep]; 113 (38): 10625-30 PMID27601648show ga The identification of the Lon protease Cereblon as the thalidomide receptor has led to significant progress in our understanding of immunomodulatory drugs (IMiDs). IMiD binding alters the surface of Cereblon to facilitate the recruitment of proteins including Ikaros and CK1?. The recruitment of these proteins results in their ubiquitin-mediated proteosomal degradation. How Cereblon mediates the efficacy of these compounds in the treatment of inflammatory skin conditions remains unclear. Significantly, this study has identified Rabex-5 as a Cereblon-interacting protein that is affected by IMiD binding. Furthermore, knockdown studies in a human macrophage cell line reveals a function of Rabex-5 in regulating Toll-like receptor?induced type 1 IFN production. These findings may help explain the antiinflammatory properties of IMiDs. äRabex-5 is a lenalidomide target molecule that negatively regulates TL(epmc).pdf DeepDyve Pubget Overpricing