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10.1101/gr.201624.115 http://scihub22266oqcxt.onion/10.1101/gr.201624.115 C5052043!5052043!27435934     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27435934&cmd=llinks): Failed to open stream: HTTP request failed! 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SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells |pdf=|usr=}}{{27435934}} gab.com Text SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=27435934 #FOAvip The packaging of DNA into chromatin plays an important role in transcriptional regulation and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the essential ATPase subunit of the mammalian SWI/SNF chromatin remodeling complex, uses the energy from ATP hydrolysis to disrupt nucleosomes at target regions. Although the transcriptional role of SMARCA4 at gene promoters is well-studied, less is known about its role in higher-order genome organization. SMARCA4 knockdown in human mammary epithelial MCF-10A cells resulted in 176 up-regulated genes, including many related to lipid and calcium metabolism, and 1292 down-regulated genes, some of which encode extracellular matrix (ECM) components that can exert mechanical forces and affect nuclear structure. ChIP-seq analysis of SMARCA4 localization and SMARCA4-bound super-enhancers demonstrated extensive binding at intergenic regions. Furthermore, Hi-C analysis showed extensive SMARCA4-mediated alterations in higher-order genome organization at multiple resolutions. First, SMARCA4 knockdown resulted in clustering of intra- and inter-subtelomeric regions, demonstrating a novel role for SMARCA4 in telomere organization. SMARCA4 binding was enriched at topologically associating domain (TAD) boundaries, and SMARCA4 knockdown resulted in weakening of TAD boundary strength. Taken together, these findings provide a dynamic view of SMARCA4-dependent changes in higher-order chromatin organization and gene expression, identifying SMARCA4 as a novel component of chromatin organization. Twit Text FOAVip SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=27435934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27435934 #FOAvip English Wikipedia <ref>{{Cite pmid|27435934}}</ref> SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells #MMPMID27435934 Barutcu AR; Lajoie BR; Fritz AJ; McCord RP; Nickerson JA; van Wijnen AJ; Lian JB; Stein JL; Dekker J; Stein GS; Imbalzano AN Genome Res 2016[Sep]; 26 (9): 1188-201 PMID27435934show ga The packaging of DNA into chromatin plays an important role in transcriptional regulation and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the essential ATPase subunit of the mammalian SWI/SNF chromatin remodeling complex, uses the energy from ATP hydrolysis to disrupt nucleosomes at target regions. Although the transcriptional role of SMARCA4 at gene promoters is well-studied, less is known about its role in higher-order genome organization. SMARCA4 knockdown in human mammary epithelial MCF-10A cells resulted in 176 up-regulated genes, including many related to lipid and calcium metabolism, and 1292 down-regulated genes, some of which encode extracellular matrix (ECM) components that can exert mechanical forces and affect nuclear structure. ChIP-seq analysis of SMARCA4 localization and SMARCA4-bound super-enhancers demonstrated extensive binding at intergenic regions. Furthermore, Hi-C analysis showed extensive SMARCA4-mediated alterations in higher-order genome organization at multiple resolutions. First, SMARCA4 knockdown resulted in clustering of intra- and inter-subtelomeric regions, demonstrating a novel role for SMARCA4 in telomere organization. SMARCA4 binding was enriched at topologically associating domain (TAD) boundaries, and SMARCA4 knockdown resulted in weakening of TAD boundary strength. Taken together, these findings provide a dynamic view of SMARCA4-dependent changes in higher-order chromatin organization and gene expression, identifying SMARCA4 as a novel component of chromatin organization. äSMARCA4 regulates gene expression and higher-order chromatin structure(epmc).pdf DeepDyve Pubget Overpricing