Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/ajt.13628 http://scihub22266oqcxt.onion/10.1111/ajt.13628 C5066576!5066576!26602755     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26602755&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26602755.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Transplant 2016 ; 16 (5): 1456-64 Nephropedia Template TP {{tp|p=26602755|t=2016. Anti-LFA-1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade Resistant Rejection |pdf=|usr=}}{{26602755}} gab.com Text Anti-LFA-1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade Resistant Rejection JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26602755 #FOAvip Costimulation blockade with the fusion protein belatacept provides a desirable side-effect profile and improvement in renal function compared to calcineurin inhibition in renal transplantation. This comes at the cost of increased rates of early acute rejection. Blockade of the integrin molecule LFA-1 has been shown to be an effective adjuvant to costimulation blockade in a rigorous non-human primate (NHP) model of islet transplantation. We therefore sought to test this combination in an NHP renal transplant model. Rhesus macaques received belatacept maintenance therapy with or without the addition of LFA-1 blockade, achieved using a murine derived LFA-1 specific antibody, TS1/22. Additional experiments were performed using chimeric, rhesus IgG1 (TS1/22R1) or IgG4 (TS1/22R4) variants, each engineered to limit antibody clearance. Despite evidence of proper binding to the target molecule and impaired cellular egress from the intravascular space indicative of a therapeutic effect similar to prior islet studies, LFA-1 blockade failed to significantly prolong graft survival. Furthermore, evidence of impaired protective immunity against CMV was observed. These data highlight the difficulties in translating treatment regimens between organ models, and suggest that the primarily vascularized renal model is more robust with regard to belatacept resistant rejection than the islet model. Twit Text FOAVip Anti-LFA-1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade Resistant Rejection ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26602755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26602755 #FOAvip English Wikipedia <ref>{{Cite pmid|26602755}}</ref> Anti-LFA-1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade Resistant Rejection #MMPMID26602755 Anderson DJ; Lo DJ; Leopardi F; Song M; Turgeon NA; Strobert EA; Jenkins JB; Wang R; Reimann KA; Larsen CP; Kirk AD Am J Transplant 2016[May]; 16 (5): 1456-64 PMID26602755show ga Costimulation blockade with the fusion protein belatacept provides a desirable side-effect profile and improvement in renal function compared to calcineurin inhibition in renal transplantation. This comes at the cost of increased rates of early acute rejection. Blockade of the integrin molecule LFA-1 has been shown to be an effective adjuvant to costimulation blockade in a rigorous non-human primate (NHP) model of islet transplantation. We therefore sought to test this combination in an NHP renal transplant model. Rhesus macaques received belatacept maintenance therapy with or without the addition of LFA-1 blockade, achieved using a murine derived LFA-1 specific antibody, TS1/22. Additional experiments were performed using chimeric, rhesus IgG1 (TS1/22R1) or IgG4 (TS1/22R4) variants, each engineered to limit antibody clearance. Despite evidence of proper binding to the target molecule and impaired cellular egress from the intravascular space indicative of a therapeutic effect similar to prior islet studies, LFA-1 blockade failed to significantly prolong graft survival. Furthermore, evidence of impaired protective immunity against CMV was observed. These data highlight the difficulties in translating treatment regimens between organ models, and suggest that the primarily vascularized renal model is more robust with regard to belatacept resistant rejection than the islet model. �Anti-LFA-1 Therapy in a Nonhuman Primate Renal Transplant Model of Cos(epmc).pdf DeepDyve Pubget Overpricing