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10.1136/thoraxjnl-2016-208505 http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2016-208505 C5099176!5099176!27471049     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27471049&cmd=llinks): Failed to open stream: HTTP request failed! 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Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins |pdf=|usr=}}{{27471049}} gab.com Text Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins JO: Thorax http://www.kidney.de/pget.php?&tw=1&pmid=27471049 #FOAvip Background: Efferocytosis (the phagocytosis of apoptotic self cells) is a key mechanism in the resolution of inflammatory processes such as community-acquired pneumonia (CAP). Efferocytosis therefore represents a modifiable target for therapy aimed at enhancing intrinsic recovery mechanisms. It is currently not known which patients recovering from CAP would mostly benefit from a strategy aimed at enhancing efferocytosis. Methods: We recruited a cohort of patients with CAP admitted to a hospital in Liverpool. One month into recovery, subjects were invited for research bronchoscopy and bronchoalveolar lavage. An ex vivo efferocytosis assay was performed by challenging alveolar macrophages with autologous, apoptotic neutrophils. The percentage of alveolar macrophages that had undergone efferocytosis was determined by flow cytometry. We conducted a multivariable regression using a linear mixed effects model to determine which clinical parameters were most closely associated with efferocytosis. Results: We observed high rates of comorbidity among this CAP cohort. Efferocytosis was measured in 22 subjects. We assessed multiple combinations of clinical parameters for association with efferocytosis and found the best-fitting model included an interaction between smoking status and prior statin use?smoking being associated with decreased efferocytosis and statin use with increased efferocytosis. These effects were modified by an association between efferocytosis and body mass index (BMI), such that as BMI increased so did efferocytosis. Conclusions: This is the first study to measure efferocytosis in patients recovering from CAP. The results suggest that smokers with low BMI have impaired efferocytosis and may benefit from a statin to boost recovery. Twit Text FOAVip Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins ????Thorax http://www.kidney.de/pget.php?&tw=1&pmid=27471049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27471049 #FOAvip English Wikipedia <ref>{{Cite pmid|27471049}}</ref> Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins #MMPMID27471049 Wootton DG; Diggle PJ; Court J; Eneje O; Keogan L; Macfarlane L; Wilks S; Woodhead M; Gordon SB Thorax 2016[Nov]; 71 (11): 1052-4 PMID27471049show ga Background: Efferocytosis (the phagocytosis of apoptotic self cells) is a key mechanism in the resolution of inflammatory processes such as community-acquired pneumonia (CAP). Efferocytosis therefore represents a modifiable target for therapy aimed at enhancing intrinsic recovery mechanisms. It is currently not known which patients recovering from CAP would mostly benefit from a strategy aimed at enhancing efferocytosis. Methods: We recruited a cohort of patients with CAP admitted to a hospital in Liverpool. One month into recovery, subjects were invited for research bronchoscopy and bronchoalveolar lavage. An ex vivo efferocytosis assay was performed by challenging alveolar macrophages with autologous, apoptotic neutrophils. The percentage of alveolar macrophages that had undergone efferocytosis was determined by flow cytometry. We conducted a multivariable regression using a linear mixed effects model to determine which clinical parameters were most closely associated with efferocytosis. Results: We observed high rates of comorbidity among this CAP cohort. Efferocytosis was measured in 22 subjects. We assessed multiple combinations of clinical parameters for association with efferocytosis and found the best-fitting model included an interaction between smoking status and prior statin use?smoking being associated with decreased efferocytosis and statin use with increased efferocytosis. These effects were modified by an association between efferocytosis and body mass index (BMI), such that as BMI increased so did efferocytosis. Conclusions: This is the first study to measure efferocytosis in patients recovering from CAP. The results suggest that smokers with low BMI have impaired efferocytosis and may benefit from a statin to boost recovery. äRecovery from pneumonia requires efferocytosis which is impaired in sm(epmc).pdf DeepDyve Pubget Overpricing