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10.1007/s11255-016-1420-y http://scihub22266oqcxt.onion/10.1007/s11255-016-1420-y C5099367!5099367!27671905     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27671905&cmd=llinks): Failed to open stream: HTTP request failed! 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Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease |pdf=|usr=}}{{27671905}} gab.com Text Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease JO: Int Urol Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27671905 #FOAvip Background: The proteasome system is involved in several disorders. The 5? untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) ?8 C/G, associated with diabetes, myocardial infarction and coronary artery disease. Methods: We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for ?8 C/G SNP by polymerase chain reaction and restriction analysis. Results: We observed lower frequency of CG�+�GG genotypes in patients than in controls (20 vs. 42�%, p�=�0.0038). The odds ratio of 0.34 (95�% CI 0.26?0.45) suggests association of CG�+�GG with decreased risk of ESKD. We investigated the association between PSMA6 polymorphism and LVH present in 54�% of patients. There was a significant association of CG�+�GG genotype with LVH, with over 75�% of CG�+�GG in patients with LVH. This effect was independent from other common causes of LVH?age (OR 1.12, p�=�0.643) and hypertension (OR 1.72, p�=�0.422). Conclusion: We demonstrated for the first time that PSMA6 polymorphism might be a protective factor for ESKD. On the other hand, CG�+�GG genotypes are independently related to LVH in ESKD patients. Twit Text FOAVip Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease ????Int Urol Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27671905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27671905 #FOAvip English Wikipedia <ref>{{Cite pmid|27671905}}</ref> Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease #MMPMID27671905 Buraczynska M; Stec A; Filipczak A; Ksiazek A Int Urol Nephrol 2016[]; 48 (12): 2083-7 PMID27671905show ga Background: The proteasome system is involved in several disorders. The 5? untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) ?8 C/G, associated with diabetes, myocardial infarction and coronary artery disease. Methods: We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for ?8 C/G SNP by polymerase chain reaction and restriction analysis. Results: We observed lower frequency of CG�+�GG genotypes in patients than in controls (20 vs. 42�%, p�=�0.0038). The odds ratio of 0.34 (95�% CI 0.26?0.45) suggests association of CG�+�GG with decreased risk of ESKD. We investigated the association between PSMA6 polymorphism and LVH present in 54�% of patients. There was a significant association of CG�+�GG genotype with LVH, with over 75�% of CG�+�GG in patients with LVH. This effect was independent from other common causes of LVH?age (OR 1.12, p�=�0.643) and hypertension (OR 1.72, p�=�0.422). Conclusion: We demonstrated for the first time that PSMA6 polymorphism might be a protective factor for ESKD. On the other hand, CG�+�GG genotypes are independently related to LVH in ESKD patients. �Association between functional variant of inflammatory system gene (PS(epmc).pdf DeepDyve Pubget Overpricing