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10.1038/srep36075 http://scihub22266oqcxt.onion/10.1038/srep36075 C5099925!5099925!27824055     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27824055&cmd=llinks): Failed to open stream: HTTP request failed! 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Involvement of eIF6 in external mechanical stretch?mediated murine dermal fibroblast function via TGF-?1 pathway |pdf=|usr=}}{{27824055}} gab.com Text Involvement of eIF6 in external mechanical stretch mediated murine dermal fibroblast function via TGF- 1 pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27824055 #FOAvip External mechanical loading on a wound commonly increases fibrosis. Transforming growth factor-?1 (TGF-?1) has been implicated in fibrosis in various models, including the mechanical force model. However, the underlying mechanism is unclear. Our previous experiments suggested that eukaryotic initiation factor 6 (eIF6) acted as a regulator of TGF-?1 expression, and negatively impact on collagen synthesis. Our current results showed that external mechanical stretching significantly increased COL1A1, TGF-?1 and eIF6 expression as well as dermal fibroblasts proliferation, both in vitro and in vivo. eIF6 ?deficient (eIF6+/?) cells exhibited significantly higher levels of COL1A1, and these levels increased further with external mechanical stretching, suggesting that mechanical stretching plays a synergistic role in promoting COL1A1 expression in eIF6+/? cells. Inhibition of TGF?R I/II by LY2109761 decreased COL1A1 protein expression in eIF6+/? dermal fibroblasts in a cell stretching model, and attenuated granulation tissue formation in partial thickness wounds of eIF6+/? mice. These data suggest that mechanical stretching has a synergistic role in the expression of COL1A1 in eIF6+/? cells, and is mediated by activation of TGF?RI/II. Taken together, our results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-?1 pathway. Twit Text FOAVip Involvement of eIF6 in external mechanical stretch mediated murine dermal fibroblast function via TGF- 1 pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27824055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27824055 #FOAvip English Wikipedia <ref>{{Cite pmid|27824055}}</ref> Involvement of eIF6 in external mechanical stretch?mediated murine dermal fibroblast function via TGF-?1 pathway #MMPMID27824055 Shu Q; Tan J; Ulrike VD; Zhang X; Yang J; Yang S; Hu X; He W; Luo G; Wu J Sci Rep 2016[]; 6 (ä): ä PMID27824055show ga External mechanical loading on a wound commonly increases fibrosis. Transforming growth factor-?1 (TGF-?1) has been implicated in fibrosis in various models, including the mechanical force model. However, the underlying mechanism is unclear. Our previous experiments suggested that eukaryotic initiation factor 6 (eIF6) acted as a regulator of TGF-?1 expression, and negatively impact on collagen synthesis. Our current results showed that external mechanical stretching significantly increased COL1A1, TGF-?1 and eIF6 expression as well as dermal fibroblasts proliferation, both in vitro and in vivo. eIF6 ?deficient (eIF6+/?) cells exhibited significantly higher levels of COL1A1, and these levels increased further with external mechanical stretching, suggesting that mechanical stretching plays a synergistic role in promoting COL1A1 expression in eIF6+/? cells. Inhibition of TGF?R I/II by LY2109761 decreased COL1A1 protein expression in eIF6+/? dermal fibroblasts in a cell stretching model, and attenuated granulation tissue formation in partial thickness wounds of eIF6+/? mice. These data suggest that mechanical stretching has a synergistic role in the expression of COL1A1 in eIF6+/? cells, and is mediated by activation of TGF?RI/II. Taken together, our results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-?1 pathway. äInvolvement of eIF6 in external mechanical stretch?mediated murine der(epmc).pdf DeepDyve Pubget Overpricing