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10.1111/imr.12474 http://scihub22266oqcxt.onion/10.1111/imr.12474 C5108576!5108576!27782327     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27782327&cmd=llinks): Failed to open stream: HTTP request failed! 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Evolution of the complement system: from defense of the single cell to guardian of the intravascular space |pdf=|usr=}}{{27782327}} gab.com Text Evolution of the complement system: from defense of the single cell to guardian of the intravascular space JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27782327 #FOAvip The complement system is an evolutionarily ancient component of immunity that revolves around the central component C3. With the recent description of intracellular C3 stores in many types of human cells, our view of the complement system has expanded. In this article, we hypothesize that a primitive version of C3 comprised the first element of the original complement system and initially functioned intracellularly and on the membrane of single-cell organisms. With increasing specialization and multicellularity, C3 evolved a secretory capacity that allowed it to play a protective role in the interstitial space. Upon development of a pumped circulatory system, C3 was synthesized in large amounts and secreted by the liver to protect the intravascular space. Recent discoveries of intracellular C3 activation, a C3-based recycling pathway and C3 being a driver and programmer of cell metabolism suggest that the complement system utilizes C3 to guard not only extracellular but also the intracellular environment. We predict that the major functions of C3 in all four locations (i.e., intracellular, membrane, interstitium and circulation) are similar: opsonization, membrane perturbation, triggering inflammation and metabolic reprogramming. Twit Text FOAVip Evolution of the complement system: from defense of the single cell to guardian of the intravascular space ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27782327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27782327 #FOAvip English Wikipedia <ref>{{Cite pmid|27782327}}</ref> Evolution of the complement system: from defense of the single cell to guardian of the intravascular space #MMPMID27782327 Elvington M; Liszewski MK; Atkinson JP Immunol Rev 2016[Nov]; 274 (1): 9-15 PMID27782327show ga The complement system is an evolutionarily ancient component of immunity that revolves around the central component C3. With the recent description of intracellular C3 stores in many types of human cells, our view of the complement system has expanded. In this article, we hypothesize that a primitive version of C3 comprised the first element of the original complement system and initially functioned intracellularly and on the membrane of single-cell organisms. With increasing specialization and multicellularity, C3 evolved a secretory capacity that allowed it to play a protective role in the interstitial space. Upon development of a pumped circulatory system, C3 was synthesized in large amounts and secreted by the liver to protect the intravascular space. Recent discoveries of intracellular C3 activation, a C3-based recycling pathway and C3 being a driver and programmer of cell metabolism suggest that the complement system utilizes C3 to guard not only extracellular but also the intracellular environment. We predict that the major functions of C3 in all four locations (i.e., intracellular, membrane, interstitium and circulation) are similar: opsonization, membrane perturbation, triggering inflammation and metabolic reprogramming. �Evolution of the complement system: from defense of the single cell to(epmc).pdf DeepDyve Pubget Overpricing