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Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid #MMPMID27129429
Ju YES; Finn MB; Sutphen CL; Herries EM; Jerome GM; Ladenson JH; Crimmins DL; Fagan AM; Holtzman DM
Ann Neurol 2016[Jul]; 80 (1): 154-9 PMID27129429show ga
We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer Disease is OSA leading to decreased slow wave activity, increased synaptic activity, decreased glymphatic clearance, and increased amyloid-?. Polysomnography and lumbar puncture were performed in OSA and control groups. Slow wave activity negatively correlated with cerebrospinal fluid amyloid-?-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-?-40 was decreased in the OSA group. Other neuronally-derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid.