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10.1002/ana.24672

http://scihub22266oqcxt.onion/10.1002/ana.24672
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C5120585!5120585!27129429
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suck abstract from ncbi


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pmid27129429      Ann+Neurol 2016 ; 80 (1): 154-9
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  • Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid #MMPMID27129429
  • Ju YES; Finn MB; Sutphen CL; Herries EM; Jerome GM; Ladenson JH; Crimmins DL; Fagan AM; Holtzman DM
  • Ann Neurol 2016[Jul]; 80 (1): 154-9 PMID27129429show ga
  • We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer Disease is OSA leading to decreased slow wave activity, increased synaptic activity, decreased glymphatic clearance, and increased amyloid-?. Polysomnography and lumbar puncture were performed in OSA and control groups. Slow wave activity negatively correlated with cerebrospinal fluid amyloid-?-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-?-40 was decreased in the OSA group. Other neuronally-derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid.
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