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10.1073/pnas.1615990113 http://scihub22266oqcxt.onion/10.1073/pnas.1615990113 C5127349!5127349!27821747     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27821747.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (47): E7526-34 Nephropedia Template TP {{tp|p=27821747|t=2016. Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer |pdf=|usr=}}{{27821747}} gab.com Text Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821747 #FOAvip In this study, we created a barcoded whole-genome ORF mRNA display library and combined it with phage-immunoprecipitation sequencing to look for autoantibodies in sera from patients with scleroderma who also had coincident cancer without a known autoantibody biomarker. Using these two technologies, we found that 25% of these patients had autoantibodies to RNA Binding Region Containing 3 (RNPC3) and multiple other components of the minor spliceosome. There was evidence of intra- and intermolecular epitope spreading within RNPC3 and the complex. These combined technologies are highly effective for rapidly discovering autoantibodies in patient subgroups, which will be useful tools for patient stratification and discovery of pathogenic pathways. Twit Text FOAVip Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821747 #FOAvip English Wikipedia <ref>{{Cite pmid|27821747}}</ref> Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer #MMPMID27821747 Xu GJ; Shah AA; Li MZ; Xu Q; Rosen A; Casciola-Rosen L; Elledge SJ Proc Natl Acad Sci U S A 2016[Nov]; 113 (47): E7526-34 PMID27821747show ga In this study, we created a barcoded whole-genome ORF mRNA display library and combined it with phage-immunoprecipitation sequencing to look for autoantibodies in sera from patients with scleroderma who also had coincident cancer without a known autoantibody biomarker. Using these two technologies, we found that 25% of these patients had autoantibodies to RNA Binding Region Containing 3 (RNPC3) and multiple other components of the minor spliceosome. There was evidence of intra- and intermolecular epitope spreading within RNPC3 and the complex. These combined technologies are highly effective for rapidly discovering autoantibodies in patient subgroups, which will be useful tools for patient stratification and discovery of pathogenic pathways. äSystematic autoantigen analysis identifies a distinct subtype of scler(epmc).pdf DeepDyve Pubget Overpricing