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10.1101/gad.287953.116

http://scihub22266oqcxt.onion/10.1101/gad.287953.116
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C5159669!5159669!27913603
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suck abstract from ncbi


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pmid27913603      Genes+Dev 2016 ; 30 (22): 2551-64
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  • The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue #MMPMID27913603
  • Wada S; Neinast M; Jang C; Ibrahim YH; Lee G; Babu A; Li J; Hoshino A; Rowe GC; Rhee J; Martina JA; Puertollano R; Blenis J; Morley M; Baur JA; Seale P; Arany Z
  • Genes Dev 2016[Nov]; 30 (22): 2551-64 PMID27913603show ga
  • Wada et al. show that FLCN regulates adipose tissue browning via mTOR and the transcription factor TFE3. Adipose-specific deletion of FLCN relieves mTOR-dependent cytoplasmic retention of TFE3, leading to direct induction of the PGC-1 transcriptional coactivators, drivers of mitochondrial biogenesis and the browning program.
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