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10.1091/mbc.E16-08-0597

http://scihub22266oqcxt.onion/10.1091/mbc.E16-08-0597
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C5231895!5231895!27881662
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suck abstract from ncbi


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pmid27881662      Mol+Biol+Cell 2017 ; 28 (2): 261-9
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  • The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function #MMPMID27881662
  • Padovano V; Kuo IY; Stavola LK; Aerni HR; Flaherty BJ; Chapin HC; Ma M; Somlo S; Boletta A; Ehrlich BE; Rinehart J; Caplan MJ
  • Mol Biol Cell 2017[Jan]; 28 (2): 261-9 PMID27881662show ga
  • The polycystin proteins are encoded by the genes mutated in autosomal dominant polycystic kidney disease. A new role for these proteins in oxygen sensing and cell metabolism is proposed. Oxygen regulates the trafficking and channel activity of the polycystin complex, which modulates mitochondrial function by altering mitochondrial calcium uptake.



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